Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Calcium acetate raw material medicine and preparation method and application thereof

A technology of calcium acetate and raw materials, which is applied in the field of medicine, can solve the problems of poor taste and large residues, and achieve the effects of less acetic acid residues, good taste, and increased crystallization

Inactive Publication Date: 2017-08-08
刘晓凯
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the prior art, spray drying is generally used to directly process the calcium acetate aqueous solution to produce calcium acetate products, wherein the residual amount of acetic acid is about 0.5 to 0.7 wt%, which is relatively large and has a poor taste when taken.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Calcium acetate raw material medicine and preparation method and application thereof
  • Calcium acetate raw material medicine and preparation method and application thereof
  • Calcium acetate raw material medicine and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0025] The preparation method of calcium acetate bulk drug includes the following steps:

[0026] Step S1: Distill the aqueous calcium acetate solution below 90°C, and then collect the concentrate.

[0027] Acetic acid will evaporate in this process. Although the temperature does not reach the boiling point of acetic acid during this process, the process is not a boiling process, so there is no need to reach the boiling point. Even if it is below 90°C, there is always evaporation.

[0028] Among them, the material-to-liquid ratio of the calcium acetate aqueous solution is 0.2 to 0.36 g / mL. The calcium acetate aqueous solution is preferably a clear calcium acetate aqueous solution. The material-to-liquid ratio refers to the ratio of the mass of calcium acetate solid matter to the volume of the aqueous solution.

[0029] When distilling, it needs to be distilled until the collected distillate is 40-70% of the volume of calcium acetate aqueous solution added. Collecting too much or to...

Embodiment 1

[0053] The method for preparing calcium acetate bulk medicine provided in this embodiment includes the following steps:

[0054] a. Take a calcium acetate aqueous solution with a material-to-liquid ratio of 0.2g / mL, distill the calcium acetate aqueous solution, and keep the calcium acetate aqueous solution at 90°C while distilling, until the collected distillate is the calcium acetate aqueous solution added to the volume of 40 %, then collect the concentrate;

[0055] b. Stir the concentrate for 3h in a water bath cooling environment at 15°C;

[0056] c. Vacuum filtration of the substance obtained in step b;

[0057] d. Under the condition of a temperature of 80°C, the substance obtained in step c is dried to a moisture content of 6 wt% to obtain a calcium acetate bulk drug.

[0058] This embodiment also provides a calcium acetate drug prepared by the above preparation method, and the residual amount of acetic acid in the calcium acetate drug is 0.1 wt%.

Embodiment 2

[0060] The method for preparing calcium acetate bulk medicine provided in this embodiment includes the following steps:

[0061] a. Take a calcium acetate aqueous solution with a material-to-liquid ratio of 0.36g / mL, distill the calcium acetate aqueous solution, and keep the calcium acetate aqueous solution at 85°C while distilling, until the collected distillate is the calcium acetate aqueous solution added to the volume of 70 %, then collect the concentrate;

[0062] b. Stir the concentrate for 6h in a water bath cooling environment at 25°C;

[0063] c. Vacuum filtration of the substance obtained in step b;

[0064] d. Under the condition of a temperature of 50°C, the substance obtained in step c is dried to a moisture content of 8% by weight to obtain a calcium acetate bulk drug.

[0065] This embodiment also provides a calcium acetate drug prepared by the above preparation method, and the residual amount of acetic acid in the calcium acetate drug is 0.08 wt%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a calcium acetate raw material medicine and a preparation method and application thereof. The preparation method of the calcium acetate raw material medicine comprises the following steps: distilling a calcium acetate aqueous solution, maintaining the calcium acetate aqueous solution at 90 DEG C or below and collecting a concentrate; mixing the concentrate, and meanwhile maintaining the concentrate at 15 to 25 DEG C; and filtering the concentrate, and drying until the moisture content is 6-8wt% to obtain the calcium acetate raw material medicine. The preparation method of the calcium acetate raw material medicine has the advantages of simple operation, and can produce a calcium acetate product with less residual acetic acid and better taste.

Description

Technical field [0001] The present invention relates to the technical field of medicine, in particular to a calcium acetate bulk medicine and its preparation method and application. Background technique [0002] Calcium is one of the most important mineral nutrients in the human body. It is distributed in the blood, muscles, nerves, and bones of the whole body. It is everywhere. People must take in enough calcium every day to ensure the stability of calcium concentration in the blood and maintain nerve cells. Normal physiological function. Calcium is an important part of bones, teeth and other organs in the human body. Calcium plays an important role in blood coagulation, neuromuscular excitement, maintenance of cell membrane function, activation of enzyme reactions and secretion of hormones. When the content cannot meet the body’s needs, changes in the body’s calcium content, calcium balance, and calcium concentration gradient will cause calcium metabolism disorders, leading to...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/41C07C51/44C07C53/10A61K31/19A61P3/02A61P3/12A61P3/14A61P19/10
CPCA61K31/19A61K33/06C07C51/41C07C51/44C07C53/10
Inventor 刘晓凯王冰
Owner 刘晓凯
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com