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Preparation method for micelle based on gadolinium ion-doped up-conversion luminescent nano-material

A nanomaterial and gadolinium ion technology is applied in the field of preparation of upconversion luminescent nanomaterial micelles based on gadolinium ion doping, which can solve problems such as low sensitivity, achieve high-sensitivity magnetic resonance, realize optical imaging dual-mode imaging, The effect of high optical imaging dual-modality imaging

Active Publication Date: 2017-08-04
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When used for MRI imaging, the tissue resolution and spatial

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0030] Embodiment 1: A preparation method of a gadolinium-doped upconversion luminescent nanomaterial micelle that can be used as a contrast agent for magnetic resonance imaging and can realize optical imaging of the present invention. The specific steps are as follows:

[0031] 1) Preparation of upconversion luminescent nanomaterials:

[0032] Prepared by pyrolysis method: ①Weigh 0.72807g (2.4mmol) YCl respectively 3 ·6H 2 O, 0.290925g (0.54mmol) YbCl 3 ·6H 2 O and 0.022902g (0.06mmol) ErCl 3 ·6H 2 After 0, transfer to a round-bottom three-necked flask with a volume of 100ml, measure 45ml of oleic acid and 22.5ml of octadecene in a volume ratio of 2:1, and heat the reaction system to 160°C under vigorous stirring with argon and maintain it for 30min; ② After cooling to room temperature naturally, 0.3 g NaOH and 0.44445 g NH were added dropwise. 410ml methanol solution of F was maintained at 50°C and closed and stirred for 30min; 3. Under argon atmosphere, the system was...

Example Embodiment

[0037] Example 2:

[0038] Accurately weigh 38.84 mg DSPE-PEG2000 and 9 mg mal-PEG-DSPE according to the molar ratio of 4:1, add 6 ml of chloroform, and ultrasonically disperse them uniformly, then add 0.5 ml of chloroform-dispersed OA-UCNP@Gd, and add 4 ml of deionized water. After the ultrasonic dispersion was uniform, the excess chloroform was evaporated by a rotary evaporator at a rotating speed of 50 rpm at 65 °C until it was clear and transparent. The final reaction system was ultrasonicated with a probe for 5 min, transferred to an ultrafiltration tube, and centrifuged at 5000 g for 20 min to obtain UCNP@PEG. .

Example Embodiment

[0039] Example 3:

[0040] Accurately weigh 54.0 mg DSPE-PEG2000 and 9 mg mal-PEG-DSPE according to the molar ratio of 6:1, add 6 ml of chloroform and disperse them uniformly by ultrasonic, then add 0.5 ml of chloroform-dispersed OA-UCNP@Gd, and add 4 ml of deionized water After the ultrasonic dispersion was uniform, the excess chloroform was evaporated by a rotary evaporator at a rotating speed of 50 rpm at 65 °C until it was clear and transparent. The final reaction system was ultrasonicated with a probe for 5 min, transferred to an ultrafiltration tube, and centrifuged at 5000 g for 20 min to obtain UCNP@PEG. .

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Abstract

The invention discloses a preparation method for a micelle based on a gadolinium ion-doped up-conversion luminescent nano-material. The preparation method comprises the following steps: preparing the gadolinium ion-doped up-conversion luminescent nano-material by using an improved pyrolysis method; and preparing nano-micelle based on the gadolinium ion-doped up-conversion luminescent nano-material by using a rotary evaporation method. The preparation method provided by the invention is simple and easily practicable; a novel idea is provided for diagnosis and treatment of tumors on the basis of the advantage that the micelle integrates magnetic resonance imaging, optical imaging and the like into one; and the novel nanometer carrier overcomes the disadvantage of single-mode imaging in the prior art, can realizes synchronous in-vivo magnetic resonance imaging and optical imaging research and provides experimental research data and a theoretical base for clinical application and research.

Description

technical field [0001] The invention relates to a micelle based on an up-conversion luminescent nanomaterial, which can be used as a magnetic resonance imaging contrast agent and can realize optical imaging, and a preparation method thereof. Background technique [0002] Upconversion nanoparticles (UCNPs) can convert the absorbed low-energy near-infrared light into high-energy visible light. Appropriate surface modification of the nanomaterials makes them water-soluble, biocompatible and monodisperse. , is the prerequisite for its application in the biological field. Phospholipids are amphiphilic molecules whose hydrophilic ends are composed of phosphate-linked substituent groups and whose hydrophobic ends are composed of fatty acid hydrocarbon chains. When phospholipids are used to modify organic phase upconversion nanoluminescent materials, the fatty acid chains are bound to the surface of nanoparticles through hydrophobic interaction, while the hydrophilic ends face the ...

Claims

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Application Information

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IPC IPC(8): A61K49/18A61K49/12A61K49/00
CPCA61K49/0002A61K49/0013A61K49/126A61K49/1809
Inventor 安艳丽唐秋莎韩勇
Owner SOUTHEAST UNIV
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