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Continuous countercurrent extraction process and device for1,5-pentamethylene diamine

A pentamethylene diamine and extraction technology, applied in countercurrent extraction, solvent extraction, liquid solution solvent extraction and other directions, can solve the problems of salt crystal blocking the pipeline, affecting the extraction effect, etc. Effect

Inactive Publication Date: 2017-07-28
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The technical problem to be solved in the present invention is that, in the process of preparing 1,5-pentanediamine by the biological method, the pH of the enzyme conversion solution is adjusted to about 13 with sodium hydroxide before extraction, and the mixed solution is refluxed in the container for 5 hours to produce A large amount of carbon dioxide, and the raw material used is L-lysine hydrochloride, which will inevitably cause a large amount of salt to precipitate when the temperature is low, and the salt crystals will not only block the pipeline, but also affect the extraction effect

Method used

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  • Continuous countercurrent extraction process and device for1,5-pentamethylene diamine
  • Continuous countercurrent extraction process and device for1,5-pentamethylene diamine
  • Continuous countercurrent extraction process and device for1,5-pentamethylene diamine

Examples

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Embodiment 1

[0039] Example 1: This example illustrates the composition and connections of a complete set of equipment for extracting and obtaining 1,5-pentanediamine from an enzyme conversion liquid system

[0040] A schematic diagram of the complete set of equipment is attached figure 1 shown. Specifically, the equipment contains modular 1,5-pentamethylenediamine enzyme conversion liquid tank (1), pump (2), numerical control valve (3), pressure gauge (4), flow meter (5), extraction tower ( 7), pump (8), numerical control valve (9), pressure gauge (10), flow meter (11), extraction tower (16), pump (17), numerical control valve (18), pressure gauge (19), flow rate Meter (20), extraction tower (29); n-butanol barrel (30), pump (25), numerical control valve (26), pressure gauge (28), flow meter (27), extraction tower (29), pump (21), numerical control valve (22), pressure gauge (24), flow meter (23), extraction tower (16), pump (12), numerical control valve (13), pressure gauge (15), flow ...

Embodiment 2

[0044] Embodiment 2: This embodiment illustrates the process of extracting 1,5-pentanediamine from the enzyme conversion liquid system

[0045] After the solid-liquid separation of the enzyme conversion liquid, adjust the pH value to 13 with sodium hydroxide aqueous solution in a stainless steel reaction tank, and react at a temperature of 80 ° C for 5 hours. During the reaction, the pH value is continuously adjusted to 13. After the reaction is completed, cool to 40 ℃ for extraction, the solution temperature was kept at 40 ℃ during the extraction, the volume ratio of enzyme conversion liquid and n-butanol was 6:5, and the extraction rate was 97.5%. As shown in Table 1, it shows that the volume ratio of enzyme conversion solution and n-butanol is 5:4, and the ratio of the flow rate of extractant n-butanol to the solution flow rate is 43:50.

[0046] Table 1 Effect of flow and volume ratio of extractant to solution on extraction rate

[0047] Flow (l / min) Content o...

Embodiment 3

[0048] Embodiment 3: this embodiment illustrates the situation of implementing the process of the present invention in the equipment of embodiment 1

[0049] Take 500L of 1,5-pentanediamine enzyme conversion solution, the concentration of 1,5-pentanediamine is 141.18g / L, first adjust the pH value to 13 with aqueous sodium hydroxide solution in a stainless steel reaction tank, and react at a temperature of 80°C for 5 hour, constantly adjust the pH value in the reaction process to be 13, the reaction is finished, cooled to 40 ℃, then poured into the barrel (1), and poured n-butanol into the barrel (30), according to the enzymatic conversion liquid feed tank ( 1) Through pumps (2), (8), (25), numerical control valves (3), (13), (22), flow meters (5), (11), (20), pressure gauges (4), (10), (19) are successively extracted step by step, the extractant n-butanol tank (30) passes through pumps (25), (21), (12), numerically controlled valves (26), (22), (13), Flow meters (27), (23), (...

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Abstract

The invention discloses a continuous countercurrent extraction process of 1,5-pentamethylene diamine static mixer and a liquid-liquid cyclone separator, and also provides special equipment for the process. The special equipment comprises a pipeline, the static mixer, the liquid-liquid cyclone separator, and is characterized in that the static mixer is used in a form of a vertical pipe heat exchanger, while the liquid-liquid cyclone separator is arranged in a same tower to accelerate separation of an organic phase and a water phase, and each tower body is equipped with an organic phase metering pump and an enzyme conversion liquid metering pump; a numerical control valve is arranged on the pipeline; a temperature probe is arranged on each tower body. The signal output ends of each probe and each numerical control valve are connected with a computer control system. The process is simple, and easy to operate, the extraction processing is difficultly influenced by an insoluble matter, and the product extraction rate is high. The equipment is simple in structure, low in construction cost, and convenient to repair.

Description

technical field [0001] The invention belongs to the technical field of extraction in biochemical separation, and relates to a process for continuously extracting 1,5-pentanediamine and special equipment thereof. Background technique [0002] 1,5-pentanediamine (also known as cadaverine) is an important raw material in the chemical industry. 1,5-pentanediamine is an important monomer for the synthesis of polymers. For example, it is widely used in the synthesis of polyamide and polyurethane . [0003] Biological synthesis of 1,5-pentanediamine is a potentially competitive, environmentally friendly and sustainable resource utilization method. [0004] Patent CN 205856354 reports: With the in-depth research on the synthesis and development of 1,5-pentanediamine at home and abroad, the current synthesis of 1,5-pentanediamine is divided into two types: chemical synthesis method and biological fermentation method. The chemical method includes cyano group reduction method, Hydrox...

Claims

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Application Information

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IPC IPC(8): B01D11/00B01D11/04
CPCB01D11/00B01D11/04B01D11/0457B01D11/0461B01D11/0484B01D2011/002
Inventor 李干禄郝宁陈可泉许晟纪晓俊郭东升姜明均欧阳平凯
Owner NANJING UNIV OF TECH
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