Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Biodegradable stress-free isolated digestive tract capsulated anastomat and preparation method thereof

A tension-free, digestive tract technology, applied in drug delivery, pharmaceutical formulations, coatings, etc., can solve the problems of non-degradable staplers and life-threatening patients, shorten the overall treatment cycle, reduce medical expenses, and avoid secondary pain Effect

Active Publication Date: 2017-07-28
WENZHOU INST OF BIOMATERIALS & ENG
View PDF20 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the non-degradable staplers designed in the current medical market, foreign objects such as staples remain in the abdominal cavity after the anastomosis operation, which causes a lot of pain to the patient, and sometimes even endangers the life of the patient.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Biodegradable stress-free isolated digestive tract capsulated anastomat and preparation method thereof
  • Biodegradable stress-free isolated digestive tract capsulated anastomat and preparation method thereof
  • Biodegradable stress-free isolated digestive tract capsulated anastomat and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Biodegradable Tension-Free Isolation Gastrointestinal Capsule Stapler, see figure 2 , including body tube 1, see figure 1 , the main tube is composed of a network skeleton structure layer 2 and a hydrophobic nanofiber membrane layer 3 coated on the outer surface of the network skeleton structure layer 2, and a hemispherical hydrophilic nanofiber membrane is respectively connected to both ends of the main tube Capping 4.

[0030] The material of the network skeleton structure is poly-L-lactide with a weight average molecular weight of 1 million.

[0031] The material of the hydrophobic nanofiber membrane is poly(L-lactide-copoly-glycolide) with a weight average molecular weight of 200,000;

[0032] The hydrophilic nanofiber membrane material is a mixture of polyvinyl alcohol with a weight-average molecular weight of 5,000 and an alcoholysis degree of 88% and gelatin with a glue strength of 100g Bloom in a mass ratio of 1:1;

[0033] A preparation method of a biodegra...

Embodiment 2

[0039] The biodegradable tension-free capsule-type stapler for isolating the digestive tract includes a main body tube 1, the main tube is composed of a network skeleton structure layer 2 and a hydrophobic nanofiber membrane layer 3 coated on the outer surface of the network skeleton structure layer 2, Both ends of the main tube are respectively connected with semi-capsule-shaped hydrophilic nanofiber membrane capping ends 4 .

[0040]The material of the network skeleton structure is a mixture of poly-L-lactide with a weight average molecular weight of 200,000 and poly-D-lactide with a weight average molecular weight of 200,000 in a mass ratio of 1:1.

[0041] The material of the hydrophobic nanofiber membrane is: poly-ε-caprolactone with a weight average molecular weight of 200,000 and polydioxanone with a weight average molecular weight of 200,000 are mixed in a mass ratio of 1:1.

[0042] Preferred hydrophilic nanofiber membrane material: mix polyvinylpyrrolidone with a wei...

Embodiment 3

[0049] The biodegradable tension-free capsule-type stapler for isolating the digestive tract includes a main body tube 1, the main tube is composed of a network skeleton structure layer 2 and a hydrophobic nanofiber membrane layer 3 coated on the outer surface of the network skeleton structure layer 2, Both ends of the main tube are respectively connected with hemispherical hydrophilic nanofiber membrane capping ends 4 .

[0050] The material of the network skeleton structure: a mixture of polyglycolide with a weight-average molecular weight of 400,000 and poly(L-lactide-co-glycolide) with a weight-average molecular weight of 400,000 in a mass ratio of 1:1 .

[0051] The material of the hydrophobic nanofibrous membrane: poly(L-lactide-copoly-glycolide) with a weight-average molecular weight of 100,000 and polydioxanone with a weight-average molecular weight of 100,000 are 1 in mass ratio: Mix at a ratio of 1.

[0052] Hydrophilic nanofiber membrane material: polyacrylic acid...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Viscosityaaaaaaaaaa
Diameteraaaaaaaaaa
Lengthaaaaaaaaaa
Login to View More

Abstract

The invention discloses a biodegradable stress-free isolated digestive tract capsulated anastomat and a preparation method thereof. The anastomat comprises a main body pipe 1 which is composed of a netty framework structural layer 2 and a hydrophobic nanofiber membrane layer 3 coating the outer surface of the netty framework structural layer; semi-spherical or semi-capsulated lyophilic nanofiber membrane stop ends 4 are separately connected to two ends of the main body pipe. The biodegradable stress-free isolated digestive tract capsulated anastomat disclosed by the invention isolate gastrointestinal contents from gastrointestinal anastomotic tissues, so that growth and union out of the gastrointestinal anastomotic tissues are favorably accelerated, the success rate of gastrointestinal anastomosis is increased, and generation of anastomotic fistula is reduced to the maximum extent. The biodegradable stress-free isolated digestive tract capsulated anastomat is prepared from a biodegradable medical macromolecular material. After the anastomotic stoma is healed, the anastomat can be fully degraded and discharged out of the body, and is free of toxic and side effects; the anastomat is simple in manufacturing step and low in manufacturing cost, and the medical expense of the patient can be lowered; the integral treatment period of the patient is effectively shortened, so that secondary pain bringing to the patient is avoided.

Description

technical field [0001] The invention belongs to the technical field of medical devices for surgical operations, and relates to a biodegradable tension-free capsule-type stapler for isolating the digestive tract and a preparation method thereof. Background technique [0002] Gastrointestinal anastomosis is the most basic and common technique in abdominal surgery, and it is also a surgery that is prone to complications after surgery. Gastrointestinal fistula is a relatively common fatal complication after gastrointestinal anastomosis. Gastrointestinal anastomotic leakage refers to a defect in the gastrointestinal anastomosis, which causes the contents of the intestinal tract to flow out from the defect site, thereby inducing infection and organ function. Obstacles, malnutrition and loss of body fluids and other lesions, after gastrointestinal surgery, the probability of gastrointestinal fistula is about 2% -50.4%. Clinical studies have shown that severe gastrointestinal fistu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L31/06A61L31/10A61L31/14
CPCA61L31/06A61L31/10A61L31/14A61L31/148A61L2400/12C08L67/04C08L69/00
Inventor 石长灿章晓东李娜冯亚凯陈浩刘雯杨啸
Owner WENZHOU INST OF BIOMATERIALS & ENG
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com