Substitution rate type coupling detection device for photodynamic response active oxygen and detection method thereof

Abstract

The invention discloses a substitution rate type coupling detection device for photodynamic response active oxygen. The device comprises a computer, a data collecting card, a control box, a near-infrared light laser, an optical fiber, a collimator, a beam expanding mirror, a CCD (charge coupled device), an optical filtering system, a collecting lens, a tracking and driving system and a three-dimensional electric platform, wherein the computer is electrically connected with the data collecting card, the data collecting card is electrically connected with the near-infrared light laser through the control box, the near-infrared light laser is in light signal connection with the beam expanding mirror through the optical fiber, the data collecting card is in light signal connection with the collecting lens through the CCD, the data collecting card is electrically connected with the three-dimensional electric platform through the tracking and driving system, and the beam expanding mirror and the collecting lens are respectively arranged on the three-dimensional electric platform. By the structure, the substitution rate type coupling detection device for the photodynamic response active oxygen and the detection method thereof relate to a brand new nano-drug high-efficiency conveying, tumor treating and monitoring system, and provide a feasible scheme for high-accuracy and high-efficiency tumor treatment.

Description

technical field [0001] The invention relates to the technical field of non-destructive detection and measurement technology, in particular to an alternative ratio coupling detection device for photodynamic reaction active oxygen and a detection method thereof. Background technique [0002] The production of reactive oxygen species is a key to grasping the dose in the process of photodynamic therapy, mainly through direct or indirect monitoring of singlet oxygen production rate and production to obtain therapeutic dose information. However, whether it is based on singlet oxygen luminescence detection method, singlet oxygen capture, or other indirect dose monitoring methods, these technologies have weak signals, low sensitivity, poor real-time performance, or difficult detection, and the degree of correlation with the production rate of active oxygen Low and other limitations, and the detection method of using probes to directly capture singlet oxygen not only quenches and con...

AI Technical Summary

Problems solved by technology

However, whether it is based on singlet oxygen luminescence detection method, singlet oxygen capture, or other indirect dose monitoring methods, these technologies have weak signals, low sensitivity, poor real-time performance, or difficult detection, and the degree of correlation with the production rate of active oxygen Low and other limitations, and the detection method of using probes to directly capture singlet oxygen not only quenches and consumes singlet oxygen, but also affects the accuracy of detection, so it cannot provide accurate, real-time, easy-to-implement photodynamic dose monitoring

Images