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Dental resin monomer containing fluorine ions, and preparation method and application thereof

A technology of resin monomer and fluoride ion, which is applied in the field of dental resin, can solve the problems of inability to realize long-term sustained release of fluoride ion and repeated charge and discharge, and achieve good antibacterial effect, good repeatability, and good stability

Inactive Publication Date: 2017-07-18
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Fluorine is introduced into the composite material through the polymerization of fluorine-containing monomers, and the introduction of fluorine can prevent dental caries more effectively. Long-term sustained release and repeated charge and discharge

Method used

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  • Dental resin monomer containing fluorine ions, and preparation method and application thereof
  • Dental resin monomer containing fluorine ions, and preparation method and application thereof
  • Dental resin monomer containing fluorine ions, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1: the preparation of NVI-F-C2 dental resin monomer

[0039] Add 3.22g (0.05mol) of 1-chloroethane and 4.7g (0.05mol) of 1-vinylimidazole into a 25mL one-necked flask, and stir at 40°C for 72h. The product was precipitated three times with a mixture of diethyl ether and ethyl acetate to obtain a white powdery solid, which was dried in a vacuum oven at room temperature for 24 h.

[0040]Add 0.79g (0.005mol) of the above-mentioned intermediate product to a 25mL single-necked flask, add 10mL deionized water to dissolve, dissolve 0.64g (0.005mol) silver fluoride in 15mL deionized water, add the latter dropwise to the former under stirring In aqueous solution, react at room temperature for 2 h, centrifuge at low speed (3500 r / min) for 30 min, take the supernatant and freeze-dry to obtain the target monomer.

Embodiment 2～5

[0042] The preparation process is the same as that in Example 1, except that the halogenated alkanes are replaced by 1-chlorobutane, 1-chlorooctane, 1-chlorododecane, and 1-chlorooctadecane respectively.

Embodiment 6

[0044] The preparation process is the same as in Example 1, except that the halogenated alkane is replaced by 1-bromoethane, and the alkylation reaction is carried out at room temperature for 72h.

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PUM

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Abstract

The invention discloses a dental resin monomer containing fluorine ions. The structural formula is shown as formula (I). The invention also discloses a preparation method for the dental resin monomer containing fluorine ions and application thereof in preparing dental resin in which fluorine ions can be repeatedly charged and discharged. The dental resin which is prepared from the dental resin monomer containing fluorine ions provided by the invention as a fluorine-containing monomer can realize the long-acting slow release and repeated filling and release of fluorine ions, the forming of decayed tooth can be effectively prevented and the antibacterial property is excellent. In the formula, R is selected from alkyl groups with carbon number from 1 to 18 and Q is selected from the formula as shown in the description.

Description

technical field [0001] The present invention relates to the technical field of dental resins, in particular to a dental resin monomer containing fluoride ions and its preparation method and application. Background technique [0002] Dental caries and secondary caries have become one of the oral diseases that cannot be ignored today. They are mainly caused by the action of bacteria in the oral cavity with sugar or carbohydrates to produce acidic substances that corrode the enamel and then gradually deepen. In the initial process of demineralization caused by acidic substances eroding tooth enamel, the use of fluoride can help teeth to refill and discharge themselves, and realize the treatment of tooth decay. As a recognized anti-caries element, fluorine has the functions of reducing the solubility of tooth enamel in acidic environment, promoting the remineralization of tooth enamel, and inhibiting the uptake of sugar by bacteria. It has been widely used in various oral materi...

Claims

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Application Information

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IPC IPC(8): C07D233/58C07D213/20C07C219/08C07C213/02C08F222/14C08F220/32C08F226/06C08F220/34A61K6/083A61K6/027A61K6/00
CPCA61K6/62A61K6/74A61K6/831A61K6/887C07C219/08C07D213/20C07D233/58C08F220/32C08F220/325C08F222/10C08F222/102C08F226/06C08F220/34
Inventor 朱蔚璞孙雪飞李晓东
Owner ZHEJIANG UNIV
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