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Calcium carbonate particle composition and preparation method thereof

A technology of calcium carbonate and composition, applied in the field of calcium carbonate particle composition and preparation thereof, can solve the problems of easy increase of gastrointestinal adverse reactions, poor absorption, etc., and achieve easy industrial production and popularization and application, good stability, and easy operation. good effect

Active Publication Date: 2017-07-14
NORTH CHINA PHARMA HEBEI HUANUO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a calcium carbonate granule composition and a preparation method thereof, so as to solve the problems that existing calcium carbonate preparations easily increase gastrointestinal adverse reactions and poor absorption

Method used

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  • Calcium carbonate particle composition and preparation method thereof
  • Calcium carbonate particle composition and preparation method thereof
  • Calcium carbonate particle composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Oyster calcium carbonate powder and white granulated sugar powder are passed through an 80-mesh sieve respectively, and 75.2 g of sieved oyster calcium carbonate powder, 2809 g of sieved white granulated sugar powder, 115.8 g of citric acid, and 0.044 g of tartrazine are weighed;

[0025] (2) Take 93.5g of white granulated sugar powder and add purified water to prepare a syrup with a mass ratio concentration of 50%. Put 75.2g of sieved oyster calcium carbonate and 1425g of white granulated sugar powder into manual sieve and mix for 3 times, then add Syrup and an aqueous pigment solution prepared by dissolving 0.022g of pigment in 10g of purified water, made into a soft material, wet granulated, dried at 50°C for 120min, and granulated to obtain 30-mesh calcium carbonate granules;

[0026] (3) Mix 115.8g of citric acid with 47g of purified water, fully dissolve it, add the remaining powdered sugar and dissolve 0.022g of pigment in 10g of purified water to make a soft ...

Embodiment 2

[0029] (1) Oyster calcium carbonate powder and white granulated sugar powder are passed through 80 mesh sieves respectively, weigh 1003g of sieved oyster calcium carbonate powder, 37500g of sieved white granulated sugar powder, 1544g citric acid, 0.595 tartrazine;

[0030] (2) Get 1250g of white granulated sugar powder and add purified water to be mixed with a mass ratio concentration of 50% syrup, put the sieved oyster calcium carbonate 1003 and white granulated sugar powder 12300g into a high-efficiency mixer and mix for 3min, then add the syrup and use Dissolve 0.198g pigment aqueous solution in 100g purified water to make soft material, wet granulate, dry in fluidized bed at 60-65℃ for 15min, and granulate to obtain 60 mesh calcium carbonate granules;

[0031] (3) Mix 1544g of citric acid with 1003.6g of purified water, fully dissolve it, add the remaining powdered sugar and dissolve 0.397g of pigment in 100g of purified water to make a soft material, wet granulate, first u...

Embodiment 3

[0034] (1) Oyster calcium carbonate powder and white granulated sugar powder are passed through an 80-mesh sieve respectively, and 100 g of sieved oyster calcium carbonate powder, 3000 g of sieved white granulated sugar powder, 120 g of citric acid, and 0.01 g of tartrazine are weighed;

[0035] (2) Get 100g of white granulated sugar powder and add purified water to be mixed with a mass ratio concentration of 35% syrup, 100g of sieved oyster calcium carbonate and 900g of white granulated sugar powder are manually sieved and mixed for 3 times, then add the syrup and use 10g The pigment aqueous solution prepared by dissolving 0.005g of pigment in purified water is made into a soft material, wet granulated, dried at 50°C for 120min, and granulated to obtain 12-mesh calcium carbonate granules;

[0036] (3) Mix 120g of citric acid with 48g of purified water, fully dissolve it, add the remaining powdered sugar and dissolve 0.005g of pigment in 10g of purified water to make a soft mat...

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Abstract

The invention discloses a calcium carbonate particle composition. The calcium carbonate particle composition is prepared from the following components in parts by weight: 100 parts of calcium carbonate, 3000-4500 parts of powdered sugar, and 120-180 parts of an acid source. The invention further discloses a preparation method of the calcium carbonate particle composition. The preparation method comprises the following steps: weighing calcium carbonate, powdered sugar and the acid source according to the weight parts, taking the powdered sugar, adding purified water into the powdered sugar for preparing the syrup, mixing calcium carbonate and part of the powdered sugar, adding with the syrup, preparing a soft material, carrying out wet granulation, carrying out drying, and carrying out size stabilization, thus obtaining calcium carbonate particles; dissolving the acid source by adopting purified water, after dissolving, adding with the rest powdered sugar, preparing a soft material, carrying out wet granulation, carrying out drying, and carrying out size stabilization, thus obtaining acid particles; and uniformly mixing the calcium carbonate particles and the acid particles. The pH value of the calcium carbonate particle composition prepared by adopting the method provided by the invention is 4.5-6.5, the dissolubility is good, precipitate is seldom generated, the stability is good after the calcium carbonate particle composition is placed for a long term, the problem that the gastrointestinal tract is uncomfortable and can not realize well absorption due to hyperacidity is solved, in addition, the process is simple, the operability is good, and the industrial production as well as popularization and application can be easily realized.

Description

technical field [0001] The invention relates to a calcium preparation and a preparation method thereof, in particular to a calcium carbonate particle composition and a preparation method thereof. Background technique [0002] Calcium is one of the important elements of the human body and has very important physiological and biochemical functions. Calcium is not only the main substance that constitutes bones, but also participates in the metabolism of bones, and is necessary to maintain nerve and muscle functions. It can also regulate the secretion and storage of neurotransmitters and hormones, the uptake and utilization of amino acids, vitamin B 12 absorption etc. The important mechanism for the living cells of the human body to obtain energy is the transmembrane movement of calcium. The calcium content of the normal cell membrane is 500 times higher than the calcium content in the cell. Maintenance, as well as cell secretion, contraction, excitation, diffusion, and diffe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/10A61K9/16A61K47/26A61K47/12A61P3/12
CPCA61K9/1623A61K9/5084A61K33/10A61K47/12
Inventor 吴金波李同周增学段瑞亭于洋洋周素敏韩伟丽王巧玲单习瑞寇兵
Owner NORTH CHINA PHARMA HEBEI HUANUO
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