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Skin allergen patch test diagnosis matrix composition and preparation method thereof

A matrix composition, skin allergy technology, applied in preparations for in vivo experiments, compound screening/testing, pharmaceutical formulations, etc., can solve the problems of low sensitivity, troublesome operation, long detection time, etc., to enhance sensitivity, reduce Barrier effect, effect of shortening detection time

Active Publication Date: 2017-07-07
SANMING HEZHONG BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The invention provides a skin allergen patch test diagnostic matrix composition and a preparation method thereof, the main purpose of which is to overcome the defects of long detection time, low sensitivity and troublesome operation in existing skin allergen patch test detection products

Method used

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  • Skin allergen patch test diagnosis matrix composition and preparation method thereof
  • Skin allergen patch test diagnosis matrix composition and preparation method thereof
  • Skin allergen patch test diagnosis matrix composition and preparation method thereof

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preparation example Construction

[0074] A preparation method of a skin allergen patch test diagnostic matrix composition, comprising the steps of:

[0075] 1) Preparation of body temperature liquefaction combination matrix: First, put the body temperature liquefaction combination matrix accounting for 80-90% of the composition mass percentage in a 60-80°C constant temperature water bath to dissolve, mix well, and then set the temperature of the constant temperature water bath is 45°C. The body temperature liquefaction combination matrix is ​​composed of polyethylene glycol (PEG) and / or propylene glycol, wherein polyethylene glycol (PEG) includes polyethylene glycol 300 (PEG300), polyethylene glycol 400 (PEG400), polyethylene glycol Glycol 600 (PEG600), polyethylene glycol 1000 (PEG1000), polyethylene glycol 1450 (PEG1450), polyethylene glycol 1500 (PEG1500), polyethylene glycol 2000 (PEG2000), polyethylene glycol 3305 (PEG3305) ), polyethylene glycol 4000 (PEG4000), polyethylene glycol 6000 (PEG6000).

[00...

Embodiment 1

[0086] A skin allergen patch test diagnostic matrix composition, comprising the following components according to the mass percentage of the composition:

[0087]

[0088] A preparation method of a skin allergen patch test diagnostic matrix composition corresponding to the component, comprising the steps of:

[0089]1) Prepare body temperature liquefaction combination matrix: first dissolve polyethylene glycol 1500 (PEG1500) in a constant temperature water bath at 60°C, then add polyethylene glycol 600 (PEG600) and mix well, then set the temperature of the constant temperature water bath to 45 ℃;

[0090] 2) Add skin absorption promoting agent: add laurocapram and propylene glycol to the body temperature liquefaction combination matrix in step 1 and mix well for later use;

[0091] 3) Preparation of buffer solution: Dissolve disodium hydrogen phosphate and potassium dihydrogen phosphate in double distilled water, and measure its pH value to 7.4;

[0092] 4) Add electrolyt...

Embodiment 2

[0099] A skin allergen patch test diagnostic matrix composition, comprising the following components according to the mass percentage of the composition:

[0100]

[0101] A preparation method of a skin allergen patch test diagnostic matrix composition corresponding to the component, comprising the steps of:

[0102] 1) Preparation of body temperature liquefaction combination matrix: first melt polyethylene glycol 2000 (PEG2000) in a constant temperature water bath at 60-70°C, then add polyethylene glycol 400 (PEG400) and mix thoroughly, then set the temperature of the constant temperature water bath 45°C;

[0103] 2) Add skin absorption agent: add propylene glycol and menthol to the body temperature liquefaction combination matrix in step 1 and mix well for later use;

[0104] 3) Preparation of buffer solution: Dissolve disodium hydrogen phosphate and potassium dihydrogen phosphate in double distilled water, and measure its pH value to 7.4;

[0105] 4) Add electrolyte ma...

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Abstract

The invention relates to a skin allergen patch test diagnosis matrix composition and a preparation method thereof. The skin allergen patch test diagnosis matrix composition comprises the following components: a body temperature liquefaction composite matrix, a skin absorption promoter, a buffer solution, an electrolyte maintenance agent and the like. According to the skin allergen patch test diagnosis matrix composition provided by the invention, an allergen detection antigen is mixed with the composition and is coated on a patch test detection point, and the skin allergen patch test diagnosis matrix composition is coated on body surface skin to perform pathogenesis detection and diagnosis on contact allergy. Compared with the prior art, the skin allergen patch test diagnosis matrix composition provided by the invention has the advantages of changing the shortcomings that the traditional patch test adopts Vaseline as a single matrix; the allergen detection antigen is in a liquid state by adoption of the body temperature liquefaction composite matrix technology, therefore the allergen detection antigen is absorbed by the skin more easily; the skin barrier layer structure is changed in combination with the skin absorption promoter, so that the allergen antigen can better permeate; and meanwhile the buffer solution and the electrolyte maintenance agent protect the normal physiological functions of the detected skin tissue cells, and thus the detection result can be truly expressed. The components supplement each other and promote each other to greatly improve the allergen detection speed and detection sensitivity.

Description

technical field [0001] The invention relates to a patch test matrix composition and a preparation method thereof, in particular to a skin allergen patch test diagnostic matrix composition and a preparation method thereof. Background technique [0002] The patch test (Patch Test) has been developed for more than 100 years. It is a simple and reliable method to determine the allergens of contact allergy patients. When a patient develops allergies due to skin or mucous membrane contact with allergens, any part of the body surface in contact with the same allergen or a substance with a similar chemical structure and the same antigenicity will have skin inflammatory changes at the contact site, that is, Allergic contact dermatitis. Patch test is to use this principle to artificially configure suspicious allergens to a certain concentration, place them at a special detection point and apply them on the body surface of the human body. After a certain period of time, determine whet...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
CPCA61K49/0006
Inventor 陈隆玉陈明辉叶秀晶
Owner SANMING HEZHONG BIO TECH
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