Tilmicosin sustained release enteric-coated powder, preparation method and application thereof
A tilmicosin and enteric-coated technology, which is applied in the field of preparation of animal drugs, can solve the problems of fast release speed, poor palatability, and weak acid resistance, and achieve the effects of preventing premature release, convenient medication, and preventing burst release
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Embodiment 1
[0041] Follow the steps below to prepare tilmicosin sustained-release enteric-coated powder:
[0042] S1. Weigh 35% of cholesterol, 5% of tilmicosin raw material, and 60% of cellulose acetate phthalate according to the proportion, heat and melt the cholesterol at 80°C, and mix evenly to obtain a mixture;
[0043] S2. Add the tilmicosin raw material to the mixture described in step S1, and stir evenly to obtain the mixture;
[0044] S3. Add cellulose acetate phthalate to the mixture described in step S2, and stir evenly at 45° C. to obtain a mixture;
[0045] S4. The mixture described in step S3 is atomized, and cooled by a fluidized bed to make a powder, the temperature of the fluidized air is 28 ° C, and the linear velocity is 55 m / s;
[0046] S5. The powder described in step S4 is cooled, sieved, and collected to obtain 5% tilmicosin slow-release enteric-coated powder, with a particle size of about 100 mesh;
Embodiment 2
[0048] Follow the steps below to prepare tilmicosin sustained-release enteric-coated powder:
[0049] S1. Weigh 30% of glyceryl palmitate, 10% of tilmicosin raw material, 60% of hypromellose phthalate according to the proportion, heat and melt glyceryl palmitate at 80°C, and mix evenly to obtain a mixture;
[0050] S2. Add the tilmicosin raw material to the mixture described in step S1, and stir evenly to obtain the mixture;
[0051]S3. adding hypromellose phthalate to the mixture described in step S2, and stirring evenly at 45° C. to obtain a mixture;
[0052] S4. The mixture described in step S3 is atomized, cooled in a fluidized bed to make powder, the temperature of the fluidized air is 15°C, and the linear velocity is 75 m / s;
[0053] S5. The powder described in step S4 is cooled, sieved, and collected to obtain 10% tilmicosin slow-release enteric-coated powder, with a particle size of about 200 mesh;
Embodiment 3
[0055] Follow the steps below to prepare tilmicosin sustained-release enteric-coated powder:
[0056] S1. Weigh 25% of castor oil wax, 20% of tilmicosin raw material, 55% of No. Ⅱ polyacrylic acid resin according to the proportion, heat and melt castor oil wax at 100°C, and mix evenly to obtain a mixture;
[0057] S2. Add the tilmicosin raw material to the mixture described in step S1, and stir evenly to obtain the mixture;
[0058] S3. Add No. II polyacrylic acid resin to the mixture described in step S2, and stir evenly at 85° C. to obtain a mixture;
[0059] S4. Atomize the mixture described in step S3, and cool it in a fluidized bed to form a powder, the temperature of the fluidized air is 25°C, and the linear velocity is 95 m / s;
[0060] S5. The powder described in step S4 is cooled, sieved, and collected to obtain 20% tilmicosin slow-release enteric-coated powder, with a particle size of about 120 mesh;
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