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Method for preparing high iron-loading amount polydopamine nanoparticles

A polydopamine and nanoparticle technology, which is applied in the field of preparation of polydopamine nanoparticles, can solve the problems of limited metal loading efficiency, inability to obtain iron loading, high PDANPs, etc., and achieves short reaction time, mild conditions and high iron loading. Effect

Inactive Publication Date: 2017-07-04
SICHUAN UNIV
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Problems solved by technology

Although this method can chelate ferric ions, the efficiency of loading metals is very limited, less than 1% (Biomacromolecules 2013, 14, 3491-3497)
Even if the specific surface area of ​​PDA NPs is increased, PDA NPs with high iron loading and adjustable loading cannot be obtained

Method used

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  • Method for preparing high iron-loading amount polydopamine nanoparticles
  • Method for preparing high iron-loading amount polydopamine nanoparticles

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[0022] The invention provides a new method for preparing iron-loaded polydopamine nanoparticles. The preparation process is as follows: at room temperature, first add dopamine hydrochloride and ferric ion compound into water, and stir to make the catechol group of dopamine Perform a complex reaction with iron ions to form a complex solution; then add tris buffer (Tris buffer) into the complex solution, and the complex starts to polymerize to generate iron-loaded polydopamine nanoparticles.

[0023] The reaction process of the present invention is as follows:

[0024]

[0025] It can be seen from the above reaction process that the polydopamine obtained in the present invention is loaded with iron ions, and the obtained polydopamine is nanoparticles.

Embodiment 1-4

[0026] The preparation of the PDA NPs of embodiment 1-4 loading iron

[0027] Raw materials: The proportioning relationship of each raw material is shown in Table 1.

[0028] Preparation method: the specific preparation steps are as follows:

[0029] (1) Take by weighing dopamine hydrochloride and ferric chloride hexahydrate corresponding to the quality of each embodiment according to Table 1, add 100ml of water to dissolve, and stir magnetically for 1 hour;

[0030] (2) Take by weighing the tris corresponding to each embodiment in Table 1, and prepare 50ml aqueous solution, add in the solution of step (1), continue to stir for 2 hours;

[0031] (3) The reacted solution was centrifuged at 12000 rpm and washed three times with deionized water to obtain the PDA NPs with different iron loads in the present invention.

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Abstract

The invention belongs to the technical field of a functional high-molecular polymer, and concretely relates to a method for preparing high iron-loading amount polydopamine nanoparticles. The method comprises the following steps: under room temperature, dopamine hydrochloride and a trivalent iron ion compound are added in water, a catechol group of dopamine and iron ion are subjected to a complexation reaction through stirring to form a complex solution; a Tris aqueous solution is added in the complex solution, a polymerization reaction is carried out on a complex through stirring, and generating the polydopamine nanoparticles. The iron-loading amount of PDA NPs is high (as high as 10.26%), and iron-loading amount can be regulated and controlled in a simple mode, and a regulation and control scope is far higher than the product in the prior art.

Description

technical field [0001] The invention belongs to the technical field of functionalized polymers, and in particular relates to a preparation method of polydopamine nanoparticles with high iron loading. Background technique [0002] Polydopamine nanoparticles (PDA NPs) are a kind of polydopamine nanoparticles polymerized by small dopamine molecules. PDA NPs contain a large number of catechol groups, which have strong binding ability to various metal ions. PDA NPs have good biocompatibility and contain a large number of catechol groups, which can easily chelate paramagnetic metal ions and be used as contrast agents for magnetic resonance imaging. [0003] At present, some researchers have reported the preparation method of PDA NPs loaded with iron ions. For example, Ju, K.-Y. et al. prepared the synthesized PDA NPs by adding them to the solution containing ferric ions through the post-modification method. Although this method can chelate ferric ions, the efficiency of metal l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G73/06C08K3/16
CPCC08G73/0672C08K3/16
Inventor 李乙文邹元
Owner SICHUAN UNIV
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