Application of total flavonoids of clover in preparation of medicine for treating rheumatoid arthritis

Abstract

The invention relates to the technical field of medicines for conditioning rheumatoid arthritis, and discloses an application of total flavonoids of radix tetrastigme in rheumatoid arthritis treating medicines. The medicines are capable of conditioning the rheumatoid arthritis. A preparation process of the total flavonoids of radix tetrastigme comprises the following steps: prpearing 10-30kg of coarse powder of tubers of radix tetrastigme; conducting reflux extraction for 3 times with the addition of ethanol which is 65-75% in volume percentage; combining extracting solutions, decompressing the combined extracting solutions and recovering ethanol; keeping an obtained solution for a whole night and filtering the solution; extracting an obtained filtrate for three times by virtue of petroleum ether and conducting degreasing; processing the greased filtrate by virtue of a polyamide column; eluting the column sequentially by virtue of water and ethanol which is 90-95% in volume percentage; and decompressing an eluent of the ethanol which is 90-95% in volume percentage and recovering ethanol until a dried material is obtained, namely the total flavonoids of radix tetrastigme. At present, tripterygium glycosides, as a traditional Chinese medicine, can take a relatively good effect on treating the rheumatoid arthritis, however the tripterygium glycosides can cause various toxic and side effects, such as relatively serious injury to female ovaries and male sperms, and subsequently, clinical application is limited. According to the invention, the total flavonoids of radix tetrastigme, on treating the rheumatoid arthritis, is good in effect and free from toxic and side effects.

Description

technical field [0001] The invention relates to the technical field of drugs for treating rheumatoid arthritis, in particular to the use of total flavonoids of trefoil in the preparation of drugs for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis is a common acute or chronic inflammation of connective tissue that can recur and involve the heart. Clinically, it is characterized by joint and muscle migratory soreness, heaviness, and pain. It belongs to an allergic disease and is one of the main manifestations of rheumatic fever. It usually starts with acute fever and joint pain. Rheumatoid arthritis can invade heart, causes rheumatic heart disease, and performances such as heating, subcutaneous nodule and erythra are arranged. Rheumatoid arthritis is a complex disease with various etiologies and frequent attacks. Western medicine believes that the cause of the disease is a systemic disease mainly caused by non-infectious inflammation of joi...

AI Technical Summary

Problems solved by technology

At present, there are many traditional Chinese medicines for treating rheumatoid arthritis on the market, but there are generally disadvantages such as insignificant curative effect, long treatment cycle, and easy recurrence after treatment.

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