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Gold nanoparticle serial compound with surface diversity

A technology of gold nanoparticles and compounds, applied in gold organic compounds, 1/11 group organic compounds without C-metal bonds, organic chemistry, etc.

Active Publication Date: 2017-06-27
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the problems existing in the surface chemical modification of existing nanomaterials, the object of the present invention is to provide a series of gold nanoparticle compounds with surface diversity

Method used

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  • Gold nanoparticle serial compound with surface diversity
  • Gold nanoparticle serial compound with surface diversity
  • Gold nanoparticle serial compound with surface diversity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] Synthesis of gold nanoparticle series compounds:

[0099]Take the process in which the core of the lysinamide compound is connected with benzoic acid and cyclohexylamine, and then combined with gold nanoparticles to generate GNP5 as an example:

[0100] Under ice bath, 100mLH 2 O and 8.0g (200mmol) NaOH are formulated into aqueous sodium hydroxide solution. Weigh 9.85g (40mmol) N-Boc-L-lysine and dissolve it in 100mL sodium hydroxide aqueous solution. Under vigorous stirring, 4.7 mL (40 mmol) of benzoyl chloride was slowly added dropwise into the above aqueous sodium hydroxide solution. The reaction was carried out for 4-6 hours, and the reaction was monitored by TLC. After the reaction, a large amount of white solid precipitated out. After suction filtration, wash with 10% hydrochloric acid solution, saturated sodium chloride solution and water successively, and dry in the air. (1) A benzoic acid substituted intermediate was obtained.

[0101] Dissolve 3.5 g (10 ...

Embodiment 2

[0110] Morphology analysis of gold nanoparticle series compounds by transmission electron microscope:

[0111] Place the GNP1-GNP28 gold nanomaterial solution in an ultrasonic breaker and sonicate for 5 minutes, take out 50 μL of the solution and add it to a clean small tube, dilute to 1 mL with high-purity water, and sonicate again for 5 minutes to disperse the material evenly. Use a 10 μL pipette gun to carefully drop 8 μL of the material onto the copper grid, and dry it under an infrared lamp for at least 30 minutes. JEM 1011 low-resolution transmission electron microscope was used to observe the morphology of gold nanoparticles with AMT 2k CCD lens under the voltage condition of 80KV.

[0112] It is observed that the gold nanoparticles are approximately circular, with an average particle size of about 4.8nm, such as figure 1 , figure 2 shown.

Embodiment 3

[0114] Hydrated particle size analysis of gold nanoparticle series compounds:

[0115] Dilute the GNP1-GNP28 gold nanomaterial solution with high-purity water to a gold nanometer solution with a concentration of 50 μg / mL, place it in an ultrasonic breaker for 5 minutes, and use a pipette gun to take about 1 mL of the sample solution to be tested and inject it into the Sizer sample of the Malvern NanoZetasizer instrument In the pool, the particle size distribution of the gold nanoparticles to be tested in high-purity water was measured by the dynamic light scattering (Dynamic Light Scattering, DLS) method, the measurement condition was 25 ° C, and the average value was taken in parallel three times.

[0116] The dynamic hydration particle size of the obtained gold nanoparticles ranges from about 200 to 300 nm, such as image 3 shown.

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Abstract

The invention discloses a gold nanoparticle serial compound with surface diversity. Four groups based on pi-bond density and space structure difference selection and seven groups based on hydrophilic-hydrophobic property difference selection are connected on a parent nucleus of a lysine-amide compound in pairs by changing a structure of a ligand of the lysine-amide compound, and molecules of the ligand are connected with gold nanoparticles, so as to obtain the gold nanoparticle serial compound. The invention also discloses a differentiated surface property of the gold nanoparticle serial compound and potential application of the differentiated surface property in research on interaction between nanoparticle materials and cells, so that a design that the gold nanoparticle serial compound serving as a targeted carrying drug, a biological developer, a disease diagnosis drug, a gene therapy drug and the like is applied to a carrier of the bio-medical field can be guided by utilizing a result of an interactive relationship.

Description

technical field [0001] The invention relates to a gold nanoparticle series compound, in particular to a gold nanoparticle series compound with surface diversity; it belongs to the technical field of functional modification of the surface of nanomaterials. Background technique [0002] Due to their small size effect, surface and interface effect, and quantum size effect, nanomaterials play an increasingly important role in the fields of life, production and biomedicine, such as nano-biomarkers, nano-imaging agents, and nano-drug carriers. . With the wide application of nanomaterials in various fields, the potential harm it may bring to human health has gradually attracted people's attention. In the process of interaction between nanomaterials and biological systems, their surface properties such as hydrophilicity and hydrophobicity, charge, hydrogen bond, π-bond, steric hindrance structure and other factors play an important role, which affect their toxicity, uptake pathways...

Claims

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Application Information

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IPC IPC(8): C07D339/04C07D409/12C07F1/12C07K5/06G01N33/53
CPCC07B2200/11C07D339/04C07D409/12C07F1/005C07K5/06G01N33/53
Inventor 闫兵刘畅王深清刘寅翟淑梅江翠娟张秋
Owner SHANDONG UNIV
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