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A kind of technique for rapidly extracting ketone from Tongkat Ali

A wide hysterone and process technology, which is applied in the field of extraction and separation of plant active components, can solve the problems of insufficient extraction of active components, long raw material processing time, unsuitable for large-scale production, etc., and achieves shortening extraction time, preventing oxidation, and improving utilization rate. Effect

Active Publication Date: 2018-01-26
长沙卫一生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the process does not sufficiently extract the active ingredients of Tongkat Ali raw materials, and the processing time for raw materials is too long, and the solution processing capacity of decanter centrifugation, tubular centrifugation, ultrafiltration, and nanofiltration in this scheme is all Tongkat Ali raw materials. The amount is 8-12 times, so that the workload is too large, the equipment investment is large, the production is difficult, the production cost is high, and it is not suitable for large-scale production

Method used

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  • A kind of technique for rapidly extracting ketone from Tongkat Ali

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 4kg of Tongkat Ali powder and crush it into a subcritical extraction kettle. Use 60% ethanol solvent to perform subcritical extraction at 90°C for 60 minutes. The mass ratio of Tongkat Ali powder to ethanol solvent is 1:5. Ethanol extract of Tongkat Ali; the ethanol extract of Tongkat Ali is cooled to room temperature, and concentrated at 60°C under a vacuum of -0.1MPa. The volume after concentration is 20% of the ethanol extract of Tongkat Ali, and the concentration is Liquid; decanter centrifugation of the obtained concentrated liquid at 3000r / min to obtain the centrifugal supernatant; the obtained supernatant was applied to the HPD100 macroporous resin column for gradient elution (first use 10% ethanol to elute 1BV, Then use 30% ethanol to elute 2.5BV, and finally use 60% ethanol to elute 4BV) to obtain the eluate; concentrate the obtained eluate to 1 / 500 of the volume of the eluate to obtain The elution concentrate is added with alcohol 0.5 times the volume of t...

Embodiment 2

[0025] Take 4kg of Tongkat Ali powder and crush it into a subcritical extraction kettle. Use ethanol solvent with a concentration of 70% by volume for subcritical extraction at 100°C for 45 minutes. The mass ratio of Tongkat Ali powder to ethanol solvent is 1:8. To obtain the Tongkat Ali ethanol extract; cool the Tongkat Ali ethanol extract to room temperature, and concentrate at 70°C and a vacuum of -0.08MPa, and the concentrated volume is 15% of the Tongkat Ali ethanol extract, Obtain the concentrated liquid; decanter the obtained concentrated liquid at 3200r / min to obtain the centrifugal supernatant; apply the obtained supernatant to the HPD100 macroporous resin column for gradient elution (first elution with 10% ethanol volume fraction 1BV, then use 30% ethanol to elute 2.5BV, and finally use 70% ethanol to elute 3.5BV) to obtain the eluent; concentrate the obtained eluent to 1 / of the eluent volume 800, to obtain the elution concentrate, add 0.8 times the volume of the elu...

Embodiment 3

[0027] Take 4kg of Tongkat Ali powder and crush it and put it into a subcritical extraction kettle. Use an ethanol solvent with a concentration of 80% by volume to perform subcritical extraction at 120°C for 30 minutes. The mass ratio of Tongkat Ali powder to ethanol solvent is 1:10. Obtain the Tongkat Ali ethanol extract; cool the Tongkat Ali ethanol extract to room temperature and concentrate at 80°C under a vacuum of -0.07MPa, and the concentrated volume is 10% of the Tongkat Ali ethanol extract, Obtain the concentrated solution; decanter the obtained concentrated solution at 3500r / min to obtain the centrifugal supernatant; apply the obtained supernatant to the HPD100 macroporous resin column for gradient elution (first elution with 10% ethanol volume fraction 1BV, then use 30% ethanol to elute 2.5BV, and finally use 80% ethanol to elute 3BV) to obtain the eluate; concentrate the obtained eluate to 1 / 1000 of the volume of the eluate , To obtain the elution concentrate, add 1...

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Abstract

The invention discloses a process for rapidly extracting eurycomanone from eurycoma longifolia. The process comprises the following steps: after crushing eurycoma longifolia materials, adopting alcohol to carry out critical extraction, concentrating, and carrying out horizontal spiral centrifugation, thereby obtaining centrifugal supernatant; and adding the centrifugal supernatant on macroporous resin columns, carrying out gradient elution, concentrating collected eluent, adding the alcohol for crystallization, filtering, diluting, adding active carbon for decolorization, filtering, concentrating, crystallizing, and drying, thereby obtaining an eurycomanone product. The purity of the eurycomanone obtained by adopting the process is up to 98% and the final yield of the eurycomanone is more than 90%. The process disclosed by the invention has the advantages that by adoption a subcritical purification technology for extraction, the transferring rate of effective substances and the utilization rate of the eurycoma longifolia are increased, the production cost is reduced and the production efficiency is improved; and in addition, the process is simple, and strong in continuous operability, and is suitable for large-scale industrial production.

Description

Technical field [0001] The invention belongs to the extraction and separation of plant active ingredients, and in particular relates to a process for rapid extraction and separation of high-concentration quinone from Tongkat Ali, suitable for industrial production. Background technique [0002] According to a report in the Straits Times Star Journal on May 30, 1999, Dr. Johari Mohamed Shah of the University of Malaysia pointed out that the male rats fed Tongkat Ali extract were sexually active and mate with female rats. The frequency is more frequent. Because of its amazing magical properties, Tongkat Ali is widely purchased and consumed by tourists from Japan and the United States, but it is also a plant protected by Malaysian national legislation due to its scarcity. During Mahathir's reign, he vigorously promoted Tongkat Ali, making it the "youngest" national treasure in Malaysia. Since ancient times, local people such as Malaysia and Indonesia have often boiled its roots for...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/10
CPCC07D493/10
Inventor 刘喜荣何泽方刘寒毅
Owner 长沙卫一生物科技有限公司
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