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Bone repairing material and preparation method thereof

A technology for bone repair and composite materials, which is applied in the field of bone repair materials and their preparation, and can solve problems such as not meeting the needs of bone repair.

Inactive Publication Date: 2017-06-13
BEIJING AKEC MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The main purpose of the present invention is to provide a bone repair material and its preparation method to solve the problem that bone repair materials in the prior art do not meet the bone repair needs of human bone defects

Method used

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  • Bone repairing material and preparation method thereof

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preparation example Construction

[0028] In addition, according to another aspect of the present invention, there is also provided a method for preparing the above-mentioned bone repair material, which includes the following steps: taking mammalian cancellous bone and sequentially boiling it in water, soaking it in a phosphoric acid solution, cooking it, and drying it to obtain a prepared Treating cancellous bone; placing pretreated cancellous bone and strontium phosphate in sodium hydrogen phosphate solution or disodium hydrogen phosphate solution for modification to obtain modified cancellous bone; calcining the modified cancellous bone to obtain strontium-doped -Hydroxyapatite-β-TCP composite material; the pH-adjusted mixture of strontium-doped-hydroxyapatite-β-TCP composite material and collagen solution was subjected to the first ice-bath treatment, followed by drying , to obtain bone repair materials.

[0029] In the above treatment steps, after taking mammalian cancellous bone for a series of treatments...

Embodiment 1

[0044] Step 1. Select healthy and fresh 9-month-old Tibetan yak spine cancellous bone, and cut the cancellous bone of the spine and femur into 1cm 3 Small pieces, boiled in a pot for 4 hours, rinsed several times with clean water, placed in a drying oven, and dried at 120-140°C for 6-8 hours. Soak the dried cancellous bone in a phosphoric acid solution, the mass concentration of the phosphoric acid solution is 3%, and the soaking time is 3 hours. Cancellous bone was cooked in a pressure cooker at 125°C for 3 hours. Dried to obtain pretreated cancellous bone;

[0045] Step 2. Add the pretreated cancellous bone to the disodium hydrogen phosphate aqueous solution with a mass concentration of 3%, and at the same time add strontium phosphate to the system, and soak for 2 hours to obtain the modified cancellous bone;

[0046] Step 3. Calcining the modified cancellous bone. Specifically, heat the modified cancellous bone high temperature furnace to 400°C and keep it warm for 0.5 ho...

Embodiment 2

[0052] Preparation process is identical with embodiment 1, and difference is:

[0053] In step 2, the pretreated cancellous bone is added to an aqueous solution of disodium hydrogen phosphate with a mass concentration of 0.5%, and soaked for 2.5 hours to obtain the modified cancellous bone;

[0054] In the step of adjusting the pH of the mixture in step 4, adjust the pH value to 8; in the first ice bath treatment, the stirring speed is 5000r / min, and the treatment time is 1h; in the second ice bath treatment, the stirring speed is 5000r / min, the treatment time is 1h; after the second ice-bath treatment step and before drying, let stand at 15°C for 5 hours. Change the amount of collagen acetic acid solution and β-transforming growth factor added. The dosage of cross-linking agent is 0.1% of collagen.

[0055] In the finally obtained bone repair material, the weight ratio of hydroxyapatite and β-tricalcium phosphate is 8:2, and the content of strontium is 1% relative to the t...

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Abstract

The invention provides a bone repairing material and a preparation method thereof. The bone repairing material is of a porous structure and the bone repairing material comprises strontium, hydroxyapatite, beta-tricalcium phosphate and collagen. The porous structure is good for proliferation and differentiation of bone cells. Meanwhile, the bone repairing material comprises the hydroxyapatite and the beta-tricalcium phosphate, and the disadvantages that the hydroxyapatite is too stable and the beta-tricalcium phosphate is too rapidly degraded are overcome; and the degradation speed of the material is balanced and is matched with a human skeleton repairing speed very well. The collagen can be used for promoting cell migration, adhesion and differentiation and adjusting cell growth. The strontium can be used for enhancing the activity of osteoblasts and inhibiting the activity of osteoclasts. To sum up, the bone repairing material provided by the invention has various advantages and can be matched with the human skeleton repairing speed, and the bone repairing requirements of human bone defects are met.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a bone repair material and a preparation method thereof. Background technique [0002] my country is entering an aging society, and age-related changes and accompanying diseases will lead to a large number of bone defect reconstruction needs. Traditional bone graft scaffold materials include xenograft bone, allograft bone, synthetic materials, etc. All of the above materials have certain limitations. Limitations: Allogeneic bone sources are limited; xenogeneic bone has source and price issues, and there are risks of spreading diseases and causing host immune rejection; the porosity, pore traffic, and pore size of synthetic materials are different from those of human cancellous bone. Different, it is unfavorable to the adhesion and proliferation of cells, and it is difficult to promote the differentiation and maturation of osteoblasts. [0003] Hydroxyapatite (HA) is the main ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/54A61L27/36A61L27/12A61L27/24
Inventor 王刚
Owner BEIJING AKEC MEDICAL
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