Pharmaceutical composition comprising extracts of symplococs chinesis and astragalus membranaceus for preventing and treating arthritis, and method for preparing same

An astragalus extract, arthritic technology, applied in the directions of medical preparations, drug combinations, pharmaceutical formulations, etc. containing active ingredients, can solve the problem of difficult and effective regulation of their diseases, no therapeutic effect, and the therapeutic effect and mechanism of action have not yet been elucidated and other problems to achieve the effect of preventing and treating arthritis without toxicity or side effects

Inactive Publication Date: 2017-05-31
YD LIFE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, pharmacotherapeutic agents only have the effect of non-specifically relieving pain or inflammatory response itself, and chondroprotective agents act only to protect joints by supplying nutrients to chondrocytes or relieving shock
Also, when steroid preparations are taken for a long time, there may be side effects such as osteoporosis, high blood pressure, diabetes, etc. due to the loss of calcium
Therefore, in most cases, drug therapy is only used for the purpose of pain relief, and permanent artificial joint replacement is the main method, but so far, there is no drug or surgery with fundamental therapeutic effect Law
[0007] Thus, in the past few decades, many studies and efforts have been made to treat degenerative arthritis, but no pathological cause or fundamental treatment has been developed yet.
For this reason, a therapeutic agent for arthritis by Chinese herbal medicine therapeutic agent and nutritional supplement has been developed recently, but its therapeutic effect and mechanism of action have not yet been elucidated (Gaby, AR et al; Antern Med Rev, 4, pp 392-402, 1999)
Therefore, these arthritic diseases only use the existing anti-inflammatory analgesics as a simple symptomatic therapy, which is not only difficult to effectively regulate the disease, but also causes side effects caused by long-term use of the drug. man caused many difficulties

Method used

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  • Pharmaceutical composition comprising extracts of symplococs chinesis and astragalus membranaceus for preventing and treating arthritis, and method for preparing same
  • Pharmaceutical composition comprising extracts of symplococs chinesis and astragalus membranaceus for preventing and treating arthritis, and method for preparing same
  • Pharmaceutical composition comprising extracts of symplococs chinesis and astragalus membranaceus for preventing and treating arthritis, and method for preparing same

Examples

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specific Embodiment approach

[0038] Hereinafter, preferred embodiments of the present invention will be described. However, various modifications can be made to the embodiment of the present invention, and the scope of the present invention is not limited to the embodiment described below. Furthermore, the embodiments of the present invention are provided to more fully describe the present invention to those skilled in the art.

[0039] According to an example of the present invention, it relates to a pharmaceutical composition for the prevention or treatment of arthritis, more specifically, it contains a mountain bean extract and an astragalus extract as active ingredients.

[0040] In the present invention, the above-mentioned mountain bean extract and astragalus extract are obtained by extracting the whole plant, or can be obtained by extracting a part of the plant, such as root, leaf, flower, branch, stem or fruit. Preferably, it can be obtained by extracting at least one of the leaves, branches and ...

Embodiment 1 to 9

[0071] Examples 1 to 9: Preparation of mixed extracts of mountain bean and astragalus

[0072] To the 150g beavan leaves obtained by drying and slicing, after mixing astragalus with the weight ratio shown in the following table 1, add 30% ethanol of 6L, extract at normal temperature for 48 hours, filter the extracted supernatant, and reduce Concentrated under pressure and freeze-dried. In this case, the yields of the obtained mixed extracts are shown in Table 1 below.

Embodiment 10 to 17

[0073] Examples 10 to 17: Preparation of mixed extracts of mountain alum, astragalus and salvia miltiorrhiza

[0074]For the 150g beavan leaves obtained by slicing with a dryer, after mixing astragalus and salvia miltiorrhiza in the weight ratio shown in the following table 2, add 6L of 30% ethanol, extract at normal temperature for 48 hours, filter the extracted supernatant, and carry out concentrated under reduced pressure and freeze-dried. In this case, the yield of the obtained mixed extract is shown in Table 1 below.

[0075] Table 1

[0076]

[0077]

[0078] As shown in the above-mentioned Table 1, in Examples 1 to 9, the results of extracting the mountain alum and Astragalus membranaceus mixed in a weight ratio of 5:1 to 1:5 showed that a high yield of 18% or more was obtained. For the mixed extract of alum and Astragalus, in particular, in Example 1, the results of using alum and astragalus mixed in a weight ratio of 1:1 showed that the mixed extract was obtai...

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Abstract

The invention relates to a pharmaceutical composition comprising extracts of Symplococs chinesis and Astragalus membranaceus for preventing and treating arthritis, and a method for preparing the same. More particularly, the invention provides a pharmaceutical composition comprising, as active ingredients, extracts of Symplococs chinesis and Astragalus membranaceus for preventing or treating arthritis, and a method for preparing the composition comprising the steps of: preparing medicinal herbs including Symplococs chinesis and Astragalus membranaceus; and adding water or C1-4 alcohol to the prepared medicinal herbs to extract the same.

Description

technical field [0001] The present invention relates to a pharmaceutical composition for the prevention or treatment of arthritis comprising a mountain alum extract and an astragalus extract and a preparation method thereof. Background technique [0002] Arthritis, as a representative of cartilage-related diseases, is roughly divided into rheumatoid arthritis (rheumatoid arthritis) and degenerative arthritis (degenerative arthritis, osteoarthritis). It is also often found that the cartilage of the knee joint is damaged due to traffic accidents or excessive exercise. Injury situation. Currently, there are about 1,000,000 arthritis patients in South Korea, and the number of women is more than twice that of men, among them, especially a common disease in menopausal women (B elmonte-S.MA et al; Arthritis Rheum, 30, pp 1214-1225, 1987). [0003] Degenerative osteoarthritis (osteoarthritis) is a disease in which articular cartilage is worn away to cause local degenerative change...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61K36/537A61P19/02
Inventor 崔寿任金哉润崔锺吉
Owner YD LIFE SCI
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