Preparation method of gel spray for wound repairing and gel spray

Abstract

The invention discloses a preparation method of a gel spray for wound repairing and the gel spray. The preparation method comprises the following steps of (1) dispersing locust bean gum into deionized water, adding sodium periodate, carrying out stirring reaction at 30-45 DEG C for 4-8h, transferring a reaction liquid to a dialysis bag of which the molecular cut off is 5,000 for dialysis to obtain oxidized locust bean gum; and (2) adding the oxidized locust bean gum obtained in the step (1) and polyoxyethylene diphenacylamine to a calcium chloride water solution, carrying out ultrasonic treatment for 10-30min and standing to obtain hydrogel for promoting healing of a wound. The hydrogel is capable of effectively promoting healing of the wound; meanwhile, the hydrogel is safe and free of thrill, has good biocompatibility and is used for wound treatment, and is capable of fully absorbing percolate of the wound due to good hygroscopic property and maintaining the wound surface physiologically moist; meanwhile, the hydrogel also has good antibacterial activity to avoid bacterial infection.

Description

technical field [0001] The invention relates to the preparation of a gel spray, in particular to a preparation method of a gel spray for wound repair. Background technique [0002] The skin is the largest organ in the human body and serves as a mechanical barrier between the body and the outside world. [0003] Various skin injuries such as ulcers, wounds or burns may cause health problems in the body. Studies have shown that skin wound healing is a complex pathophysiological process, which roughly includes an inflammatory phase, a proliferative phase, and a remodeling phase. In the process of wound healing, especially when the injury is severe, continuous tissue hypoxia, necrosis, infection and other factors will prolong the wound healing process and make healing difficult. For the treatment of wounds, the traditional method generally uses dressings such as sponges and gauze to cover the wounds. Such dressings can absorb wound exudate, which can easily lead to dryness of ...

AI Technical Summary

Problems solved by technology

When the existing gel is used for wound dressing, due to its high viscosity, it is usually applied to the skin by means of extrusion, etc., which leads to uneven coating and is extremely inconvenient to use

In addition, existing hydrogel dressings, such as chitosan hydrogels, etc., have extensive defects such as complicated preparation process, high cost, and poor product stability.

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