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Application of Huajuhong Extract in the Preparation of Medicines for Prevention and Treatment of Acute Attack of Chronic Obstructive Pulmonary Disease Induced by PM2.5 Particles

A chronic obstructive pulmonary disease and orange-red technology, applied in application, drug combination, respiratory system diseases, etc., achieves the effect of low cost, definite curative effect, and simple preparation method

Active Publication Date: 2020-09-15
广州东荣信息科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern pharmacological studies have shown that Huajuhong has the effect of relieving cough, resolving phlegm and relieving asthma, but there is no report on the use of Huajuhong for the preparation of drugs for the prevention and treatment of PM2.5-induced exacerbation of airflow limitation during acute exacerbation of COPD

Method used

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  • Application of Huajuhong Extract in the Preparation of Medicines for Prevention and Treatment of Acute Attack of Chronic Obstructive Pulmonary Disease Induced by PM2.5 Particles
  • Application of Huajuhong Extract in the Preparation of Medicines for Prevention and Treatment of Acute Attack of Chronic Obstructive Pulmonary Disease Induced by PM2.5 Particles

Examples

Experimental program
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Effect test

Embodiment 1

[0013] Embodiment 1: the preparation of total flavonoids extract of orange red

[0014] The preparation method of the total flavonoid extract of Huajuhong is as follows: take the medicinal material of Huajuhong, decoct it with water, filter it, concentrate the decoction to a relative density of 1.05-1.30, add ethanol or (and) methanol for alcohol precipitation, and precipitates appear , filtered, and the filtrate was recovered from alcohol to an alcohol-free extract, and water was added to adjust the relative density to 1.05-1.15. After standing for more than 3 days, a precipitate was precipitated, filtered, and the precipitate was obtained. Drying is the extraction of total flavonoids of Huajuhong thing.

[0015] The method for determining the total flavonoid content of the total flavonoids extract of Huajuhong is as follows: the content is determined by the method contained in the first part of the "Chinese Pharmacopoeia" 2010 edition under the item of Huajuhong. That is, t...

Embodiment 2

[0019] Example 2: Inhibitory effect of the total flavonoid extracts of Citrus Red on PM2.5-induced exacerbation of airflow limitation during acute exacerbation of COPD.

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Abstract

The invention relates to novel application of an exocarpium extract. The invention discloses application of an exocarpium total flavone extract to preparation of a medicine for preventing and treating PM2.5 particle-induced acute attack of a chronic obstructive pulmonary disease, a medicine for preventing and treating airflow limitation aggravation during an acute aggravation attack period of the chronic obstructive pulmonary disease, and a medicine for preventing and treating a high-airway reactivity and low-lung dynamic compliance disease of a respiratory system for the first time. Preferably, the exocarpium total flavone extract with the total content of flavone compounds being higher than 50% is used. Compared with the prior art, the invention has the advantages as follows: the exocarpium total flavone extract is simple in preparation method, low in cost and accurate in therapeutic effect; the exocarpium total flavone extract is a natural plant extract, is free of side effects, and can be used as preventive health food or therapeutic medicines.

Description

technical field [0001] The present invention relates to a new application of the citrus red extract, in particular to the use of the citrus red extract for preparing a medicine for preventing and treating the acute exacerbation of chronic obstructive pulmonary disease induced by PM2.5. Background technique [0002] Chronic obstructive pulmonary disease (COPD) is a common disease characterized by persistent airflow limitation. Airflow limitation develops progressively and is associated with an increased chronic inflammatory response of the airways and lungs to noxious particles or gases. COPD is one of the diseases with the highest morbidity and mortality worldwide, and has become an important public health problem. There are currently 600 million people in the world suffering from COPD; according to the "Chinese Resident Nutrition and Chronic Disease Status Report (2015)", the prevalence of COPD among people aged 40 and over in my country is as high as 9.9%. [0003] The 2...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61P11/00A23L33/105
CPCA23V2002/00A61K36/752A23V2200/314A23V2250/21162
Inventor 姚宏亮李沛波苏薇薇王永刚彭维吴忠
Owner 广州东荣信息科技有限公司
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