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Pharmaceutical composition for Alzheimer's disease and application thereof

A technology for Alzheimer's disease and composition, which is applied in the field of western medicine to achieve the effects of improving learning and memory, shortening the latency time of dark avoidance, and improving the resolution index

Inactive Publication Date: 2017-05-31
郑州莉迪亚医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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Method used

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  • Pharmaceutical composition for Alzheimer's disease and application thereof
  • Pharmaceutical composition for Alzheimer's disease and application thereof
  • Pharmaceutical composition for Alzheimer's disease and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0019] In an embodiment of the present invention, a pharmaceutical composition for Alzheimer's disease consists of levamisole hydrochloride suppository and piracetam, wherein the mass ratio of levamisole hydrochloride suppository to piracetam is 20:1.

Embodiment 2

[0021] In an embodiment of the present invention, a pharmaceutical composition for senile dementia consists of levamisole hydrochloride suppository and piracetam, wherein the mass ratio of levamisole hydrochloride suppository to piracetam is 28:1.

Embodiment 3

[0023] In an embodiment of the present invention, a pharmaceutical composition for Alzheimer's disease consists of levamisole hydrochloride suppository and piracetam, wherein the mass ratio of levamisole hydrochloride suppository to piracetam is 23:1.

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Abstract

The invention discloses a pharmaceutical composition for Alzheimer's disease and application thereof. The western medicine composition is composed of levamisole hydrochloride suppositories and piracetam based on the mass ratio of (20-28):1. An APP / PS1 double-transgenic mouse is selected to be an animal model of Alzheimer's disease, passive avoidance incubation time of the mouse is detected based on passive avoidance test ethology to serve as the index of learning and memorizing ability of the mouse, and the discrimination index of the mouse is detected through a new object identification test so as to test the cognitive competence of the mouse. Results prove that the western medicine composition can remarkably shorten the passive avoidance incubation time of the APP / PS1 double-transgenic mouse and increase the discrimination index of the APP / PS1 double-transgenic mouse, and has a good treatment effect on Alzheimer's disease of the APP / PS1 double-transgenic mouse.

Description

technical field [0001] The invention relates to the technical field of western medicine, in particular to a pharmaceutical composition for senile dementia and its application. Background technique [0002] Alzheimer's disease (AD), also known as senile dementia, is a common multiple chronic progressive neurodegenerative disease in the elderly, clinically manifested as memory impairment, agnosia, impairment of spatial memory, abstract thinking and Computational impairment, personality and behavioral changes, among other features. With the aging of the global population, the incidence of AD is increasing year by year. Due to the lack of effective treatment, AD has become the fourth fatal disease that endangers human health after heart, cerebrovascular diseases and tumors. Therefore, finding effective drugs to prevent and treat AD has become an urgent problem in life sciences. [0003] At present, the drugs for the treatment of senile dementia mainly include cholinesterase i...

Claims

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Application Information

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IPC IPC(8): A61K31/429A61K31/4015A61P25/28
CPCA61K31/429A61K31/4015A61K2300/00
Inventor 不公告发明人
Owner 郑州莉迪亚医药科技有限公司
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