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Preparation method of antitumor drug-loaded bead-like nano fibrous membrane

A technology of anti-tumor drugs and nanofiber membranes, applied in anti-tumor drugs, pharmaceutical formulations, drug combinations, etc., can solve the problems of low efficiency of tumor sites, lack of tissue specificity, and unsatisfactory chemotherapy effects, etc., and achieve flexible mobility , easy operation and simple preparation method

Inactive Publication Date: 2017-05-31
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With this approach, there are many serious existing problems that cannot be adequately addressed, such as lack of tissue specificity and inefficient drug release at the tumor site, which make chemotherapy less effective

Method used

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  • Preparation method of antitumor drug-loaded bead-like nano fibrous membrane
  • Preparation method of antitumor drug-loaded bead-like nano fibrous membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Accurately weigh 600mg PLGA (molecular weight: 44,000) with a balance, dissolve it in a mixed solvent of dichloromethane and methanol (volume ratio: 8:2), make the PLGA mass concentration 14%, and seal the bottle to prevent solvent Volatile. Use a vortex instrument to vortex until completely dissolved to obtain the spinning stock solution. Under the conditions of 25 degrees Celsius and relative humidity of 30-50%, the electrospinning solution was spun with a hand-held electrospinning device using silk cloth as a receiver. The input voltage is 3V, the output voltage is 10KV, the receiving distance is 6cm, the electrospinning solution is 2mL, the spinning solution advancing speed is 0.4 mL / min, and the spinneret diameter is 0.51mm. After ventilating and drying, a beaded nanofiber membrane is obtained, which is called a blank beaded nanofiber membrane. figure 1 Middle a shows the scanning electron micrograph of a blank beaded nanofibrous membrane.

[0022] Accurately we...

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PUM

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Abstract

The invention discloses a preparation method of an antitumor drug-loaded bead-like nano fibrous membrane. The nano fibrous membrane adopts a biodegradable macromolecular material as a carrier. An antitumor drug and the biodegradable macromolecular material are added into an organic solvent to obtain a spinning stock solution; and then silk cloth is used as a receiver, the spinning stock solution is spun by using a handheld electrostatic spinning instrument, the organic solvent is volatilized, and the antitumor drug-loaded bead-like nano fibrous membrane is prepared. The preparation method has the advantages that the prepared drug-loaded nano fibrous membrane has high antitumor effect, the preparation method is simple, the cost is low and the application prospect is broad.

Description

technical field [0001] The invention belongs to the technical field of nano-drug carriers, and in particular relates to a preparation method of a beaded nano-fiber membrane loaded with anti-tumor drugs. Background technique [0002] Tumor is a common and frequently-occurring disease, which seriously threatens the safety of human life. According to data from Cancer Center UK in 2012, there were 14.1 million new cancer cases worldwide, of which 8.2 million cancer patients died. At present, the commonly used methods for clinical treatment of tumors include chemotherapy, radiotherapy and surgical resection. Among them, chemotherapy is a commonly used clinical cancer treatment method, but traditional chemotherapy has strong side effects on healthy tissues and cells, such as bone marrow suppression, mucositis and hair loss. Currently, a major challenge in chemotherapy is the development of drug delivery systems for the safe and effective delivery of chemotherapy drugs. [0003]...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/4745A61K47/34A61P35/00D04H1/4382D04H1/728
CPCA61K31/4745A61K9/0024A61K9/7007A61K47/34D04H1/4382D04H1/728
Inventor 肖波马盼盼陈秋冰
Owner SOUTHWEST UNIVERSITY
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