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Cosmetic composition for improving skin wrinkles

A cosmetic composition and skin-improving technology, applied in the direction of cosmetics, cosmetic preparations, skin care preparations, etc., can solve safety problems such as limited dosage, insignificant effect, unexpected improvement of skin function or healing of wounds, etc. Achieve the effect of inhibiting MMP-1 expression and increasing side effects

Inactive Publication Date: 2017-05-24
UNIV IND COOP GRP OF KYUNG HEE UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, these substances are limited in their amount due to safety issues such as irritation and redness when applied to the skin and the effect is not significant, so they are not expected to work in improving skin function or healing wounds

Method used

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  • Cosmetic composition for improving skin wrinkles
  • Cosmetic composition for improving skin wrinkles
  • Cosmetic composition for improving skin wrinkles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1: Preparation of the combined extract of dandelion, rhubarb, loquat leaf and Radix Sinensis

[0051] To prepare a combined extract of dandelion, rhubarb, loquat leaf, and white pomegranate, the herbs were purchased from Omniherb Inc.; dandelion (sourced from Korea), rhubarb (sourced from China), loquat leaf (sourced from China), white pomegranate (sourced from China). Before use, wash individual herbs with water and dry in the shade.

[0052] Put 40g dandelion, 20g rhubarb, 20g loquat leaves and 15g white pomegranate into 1L distilled water. The resulting mixture was subjected to reflux extraction through a reflux tube for 4 hours at 100° C., and concentrated under vacuum to obtain 14 g of a combined extract of dandelion, rhubarb, loquat leaves, and Radix Potassium.

[0053] For individual herb extracts, 100 g of each herb was mixed with 1 L of distilled water. The mixtures thus obtained were each subjected to reflux extraction through a reflux tube at ...

Embodiment 3

[0060] Embodiment 3: to the combination extract of dandelion, rhubarb, loquat leaf and Radix Radix Sinica inhibits the biological activity of collagenase (MMP-1) Evaluation of Synthetic Effects

[0061] The test procedure was carried out as follows to evaluate the effect of the combined extracts of dandelion, rhubarb, loquat leaf, and white pomegranate on inhibiting the biosynthesis of collagenase (MMP-1).

[0062] Human fibroblasts were cultured in DMEM solution (10% fetal calf serum, 1% antibiotics) and treated with 10 4 Cells / well were seeded into 24-well plates. After confirming that the cells adhered to the wall, the DMEM solution was discarded. Then, 0.5 mL of combined extracts of dandelion, rhubarb, loquat leaves, and white pomegranate, which were made into different concentrations, was added to each well. Human fibroblasts in 5% CO 2 Incubate at 37°C for 48 hours in a purged incubator to measure cellular levels of MMP-1 in the medium.

[0063] The results are s...

preparation example 1

[0067] Formulation example 1: Preparation of face wash containing combined extracts of dandelion, rhubarb, loquat leaf and white pomegranate

[0068] According to the composition of Table 1 as given below, a procedure was carried out to prepare 1 kg of a face wash containing a combined extract of dandelion, rhubarb, loquat leaf and white pomegranate (Example 1).

[0069] [Table 1] Composition of face wash containing combined extracts of dandelion, rhubarb, loquat leaf and white pomegranate

[0070]

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Abstract

The present invention relates to a mixture of taraxicum officinalis, eisenia bicyclis, eriobotrya japonica leaf, and Ampelopsis japonica Makino extracts. The present invention comprises safe natural agents, thus does not cause side effects, and provides the advantages of improving wrinkles and increasing elasticity by promoting collagen production, inhibiting the expression of collagenase (MMP-1), and increasing the expression of type-1 procollagen.

Description

technical field [0001] The present invention relates to a cosmetic composition for improving skin wrinkles, the composition comprising a combined extract (combined extract) of medicinal herbs (medicinal herbs). Background technique [0002] The causes of skin wrinkles are broadly categorized as natural aging and exposure to UV radiation (ie, photoaging). The mechanism of skin wrinkle formation as a result of these two causes is not well understood. Common phenomena found to be associated with skin changes caused by natural aging and photoaging are loss of skin elasticity due to reduction and deformation of collagen and elastin, which are the main structural proteins of the dermis, and reduction of hyaluronic acid, which is the base of the dermis. deteriorating. According to the research results obtained so far, in particular, it is known that reduction and deformation of collagen and elastin, which are main structural proteins of the dermis, are directly involved in skin w...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61Q19/08A61Q19/00
CPCA61K8/9789A61Q19/00A61Q19/08A61K2800/591A61K2800/782
Inventor 张永杓丁世荣金曈一
Owner UNIV IND COOP GRP OF KYUNG HEE UNIV
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