System and method for tumor heterogeneity assessment
A heterogeneity, tumor technology, applied in biochemical equipment and methods, proteomics, microbial measurement/testing, etc., can solve problems such as difficulty in obtaining metastases, inability to represent the complexity of tumors, and inaccurate analysis results
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[0131] In this embodiment, 10 cases of lung cancer patients are taken as examples to illustrate the present invention. It should be noted that this embodiment is only for the purpose of illustration, and should not be construed as limiting the application in any way.
[0132] 1. List of variants detected by ctDNA high-throughput sequencing
[0133] 1) Variation V (SNV / indel / SV)
[0134] 2-8 mutations were detected in 10 lung cancer patients, and the detection list of mutation V (SNV / indel / SV) is shown in Table 1.
[0135] Table 1 Variation V (SNV / indel / SV) detection list
[0136]
[0137]
[0138] 2) CNV
[0139] Among the 10 lung cancer patients, only S5 was detected with EGFR amplification, and the amplification factor was 1.73, as shown in Table 2. Therefore, the actual total copy number corresponding to the EGFR Deletion variant detected in S5 was estimated to be 4.
[0140] Table 2 CNV detection list
[0141] Sample serial number Gene copy number v...
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