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Composition having functions of diminishing inflammation, inhibiting bacteria and promoting wound healing and preparation method thereof

A wound healing, anti-inflammatory and antibacterial technology, applied to medical preparations containing active ingredients, drug combinations, pharmaceutical formulas, etc., can solve problems such as inappropriate local treatment of wounds and affecting wound healing

Inactive Publication Date: 2017-05-17
杭州惠博士生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, some patients and medical staff currently perform inappropriate local treatment on the wound, which greatly affects the healing of the wound.

Method used

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  • Composition having functions of diminishing inflammation, inhibiting bacteria and promoting wound healing and preparation method thereof
  • Composition having functions of diminishing inflammation, inhibiting bacteria and promoting wound healing and preparation method thereof
  • Composition having functions of diminishing inflammation, inhibiting bacteria and promoting wound healing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0019] a. To prepare a dry powder of the compound, take 100-300 grams of chamomile, 300-500 grams of green thorn fruit, 300-500 grams of green tea, and 100-200 grams of wild chrysanthemum, mix and crush into 1000 grams of coarse powder, add 10 times the amount Water, boil for 2 hours, filter treatment, add 8 times the amount of water to the filter residue, boil for 1 hour, filter treatment; add 8 times the amount of water to the filter residue, boil for 1 hour, filter treatment, combine the filtrate, reduce at 50℃ Press and concentrate to a clear cream with a relative density of 1.0g / ml, add ethanol to make the alcohol content reach 60%, let stand for 24 hours, filter, the filtrate is decompressed to recover the ethanol and concentrate until there is no alcohol smell, and use the filtrate of the above composition After spray drying, it will become a dry powder, sealed and stored for later use;

[0020] b. Add the compound one to water at 30°C and stir at high speed for 30 minutes...

Embodiment 1

[0083] (1) Example 1: Wound disinfection spray

[0084] 1. Formula (quality ratio)

[0085]

[0086] 2. Production method (technical plan)

[0087] a. Fully dissolve sodium chloride in water at 30°C;

[0088] b. Add compound one (see the above description for dry powder preparation), hyaluronic acid, and compound two into step a, mix uniformly and fully dissolve;

[0089] c. Dissolve benzalkonium chloride in ethanol and add to the above solution, mix well and fully dissolve;

[0090] d. Adjust the pH to 6.5 and put it in a spray bottle for later use.

Embodiment 2

[0091] (2) Example 2: Wound dressing

[0092] The wound dressing includes a base layer, an efficacy layer and an isolation layer, wherein the base layer is pasted with the efficacy layer, and the efficacy layer is pasted with the isolation layer. Wherein, the base layer is a PE film, an EVA film or a PP film; the functional layer includes a wound healing composition coating film and a chitosan absorbent non-woven fabric; the isolation layer is silicone oil paper; the adhesive is acrylic Ester pressure-sensitive adhesive or soft silicone adhesive.

[0093] 1. Efficacy layer coating formula (quality ratio)

[0094]

[0095]

[0096] 2. Production method (technical plan)

[0097] a. Add polyvinyl alcohol to water and heat it in a 70℃ water bath to completely dissolve it to obtain a transparent solution;

[0098] b. Add xanthan gum to the above solution and heat it in a water bath at 70°C to completely dissolve it;

[0099] c. Add compound one, hyaluronic acid, and compound two to the abov...

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PUM

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Abstract

The invention discloses a composition having the functions of diminishing inflammation, inhibiting bacteria and promoting wound healing. The composition is characterized by being prepared from a hyaluronic acid, a compound I and a compound II, wherein the hyaluronic acid has the functions of diminishing inflammation and inhibiting bacteria; the compound I and the compound II are in synergistic interaction and inflammation diminishing and bacteria inhibiting functions with the hyaluronic acid; the compound I is prepared from the components of chamomile, green tea, prinsepia utilis royle and flos chrysanthemi indici; the compound II is prepared from ascorbic acid and dipotassium glycyrrhizinate. According to a biological composition containing activated hyaluronic acid and various functional components, by utilizing the synergistic effect of the biological composition in aspects of inflammation diminishing and bacteria inhibiting effects, the wound healing can be effectively promoted, the wound skin can be repaired, and the wound skin can be recovered to be beautiful.

Description

Technical field [0001] The present invention relates to the field of wound care products, in particular to a composition with anti-inflammatory, antibacterial and healing promotion and a preparation method thereof Background technique [0002] Wound surface is damage caused by normal skin (tissue) caused by external injury factors such as surgery, external force, heat, electric current, chemical substances, low temperature, and internal factors such as local blood supply obstacles, often accompanied by skin integrity The destruction of the skin and the loss of a certain amount of normal tissues, at the same time, the normal function of the skin is impaired. According to the healing cycle of wounds, it is divided into acute wounds and chronic wounds. Wound healing refers to a series of pathophysiological processes in which local tissues undergo regeneration, repair, and reconstruction after tissue loss due to the action of injury-causing factors. Its essence is the body’s damage ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61P17/02A61P17/04A61P31/10A61P31/02A61K31/728A61K31/375A61K31/704
CPCA61K31/375A61K31/704A61K31/728A61K36/28A61K36/287A61K36/73A61K36/82A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 贺晓军
Owner 杭州惠博士生物科技有限公司
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