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Application of heart-invigorating and calming tablet in preparation of medicine for curing heart diseases

A heart disease, Yixinning technology, used in cardiovascular system diseases, drug combinations, pharmaceutical formulations, etc.

Active Publication Date: 2017-05-17
辽宁上药科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the use of Yixin Ningshen Tablets in the treatment of other diseases

Method used

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  • Application of heart-invigorating and calming tablet in preparation of medicine for curing heart diseases
  • Application of heart-invigorating and calming tablet in preparation of medicine for curing heart diseases
  • Application of heart-invigorating and calming tablet in preparation of medicine for curing heart diseases

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0020] 1. Related materials

[0021] From June 27 to July 30, 2016, 98 male SD rats, weighing 220-260g, were selected from the Experimental Animal Center of Shenyang Pharmaceutical University, certificate number: SCXK (Liao) 2015-001. During the adaptation period (3d), the animals were kept in an environment with a light-dark cycle (light on 8:00) at a room temperature of 23±2°C, with free access to food and water. The rats were acclimatized for 3 days after being led, and administered continuously for 21 days. On the 22nd, the sleep deprivation model was started, and the modeling time was 10 days. Yixin Ningshen Tablets were continued to be given for treatment at the same time. On the 6th day of modeling and drug administration, the new object discrimination experiment was tested, on the 7th day, the elevated plus maze was tested, on the 8th day, the Y maze was tested, on the 9th day, the open field activity was tested, and on the 10th and 11th day, the electrocardiogram, orb...

experiment example 2

[0122] 1. Experimental time: July-August 2016.

[0123] 2. Experimental animals: SD rats, 75 males, weighing 160-180g, provided by the Experimental Animal Center of Shenyang Pharmaceutical University, certificate number: SCXK (Liao) 2015-001. During the adaptation period (3d), the animals were kept in an environment with a light-dark cycle (light on 8:00) at a room temperature of 23±2°C, with free access to food and water.

[0124] 3. Experimental grouping: 75 male SD rats, divided into 5 groups according to body weight, 15 in each group; model group, Yixin Ningshen Tablet 1 / 3×clinical equivalent (0.09g / kg), Yixin Ningshen Tablet 1× clinical equivalent dose (0.27g / kg), Yixin Ningshen Tablet 3× clinical equivalent dose (0.81g / kg), propranolol 1× clinical equivalent dose (15mg / kg) group . The specific experimental groups are shown in Table 12.

[0125] Table 12: Experimental grouping

[0126]

[0127] 4. Experimental method

[0128] 1) Electrocardiogram detection

[012...

experiment example 3

[0145] 1. Clinical data

[0146] From May 2015 to May 2016, 120 patients met the inclusion criteria in the outpatient and inpatient departments of the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine. They were divided into the observation group and the control group according to the order of visit time by computer, with 60 people in each group.

[0147] 2. Diagnostic criteria:

[0148] 1) Diagnostic criteria for coronary heart disease:

[0149] Refer to the diagnostic criteria for coronary heart disease in the Guidelines for the Diagnosis and Treatment of Chronic Stable Angina Pectoris published by the Chinese Medical Association Cardiovascular Branch and the Editorial Committee of the Chinese Journal of Cardiovascular Diseases in 2007.

[0150] 2) Diagnostic criteria for anxiety and depression:

[0151] Refer to the "Chinese Mental Disorders Classification and Diagnostic Criteria Third Edition" issued by the Chinese Journal of Psychiatry in 2001 ...

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Abstract

The invention relates to application of a heart-invigorating and calming tablet in preparation of medicine for curing heart diseases. A large quantity researches indicate that the heart-invigorating and calming tablet has the effects of dilating coronary arteries, increasing coronary blood-flow volume, reducing myocardial oxygen consumption, protecting ischemic myocardium and the like, and is a relatively effective Chinese patent medicine for curing coronary heart disease and stenocardia.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to the application of Yixin Ningshen Tablets in the preparation of medicines for treating heart diseases. Background technique [0002] Yixin Ningshen Tablets are produced by Liaoning SPH Good Nurses Pharmaceutical (Group) Co., Ltd., and the approval number is Z21021665. The active ingredients of this product are total saponins from stems and leaves of ginseng, Albizia vine, Schisandra chinensis and Ganoderma lucidum. Yixin Ningshen Tablets can invigorate qi and promote body fluid, nourish the heart and calm the nerves. It is used for insomnia, dreaminess, heart palpitations, and memory loss caused by heart qi deficiency and heart yin deficiency; neurasthenia sees the above syndromes. At the present stage, it should be mainly used in patients with insomnia, neurasthenia and anxiety. [0003] The total saponins of ginseng stems and leaves in Yixin Ningshen Tablets are e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/79A61K36/57A61K9/20A61P9/10A61P9/06
CPCA61K9/2004A61K36/074A61K36/258A61K36/48A61K36/57A61K36/79A61K2300/00
Inventor 郑继宇王芳席雪娇杨静玉李为理李国栋吴琦秦培红罗红
Owner 辽宁上药科技开发有限公司
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