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Early detection of preeclampsia

A technology for preeclampsia and endometrium, applied in the field of biomarkers of preeclampsia, can solve the problems that no one has achieved wide clinical application

Active Publication Date: 2017-05-10
IGENOMIX SL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Biochemical markers and Doppler ultrasound measurement of blood flow in maternal uterine arteries have been extensively tested, but to date none of these have achieved widespread clinical application (Conde-Agudelo et al., Obstet General 2004 ;104:1367-91)

Method used

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  • Early detection of preeclampsia
  • Early detection of preeclampsia
  • Early detection of preeclampsia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1: Maternal causes of preeclampsia revealed by resistance to endometrial decidualization mediated by ANXA2 deficiency

[0053] Materials and methods

[0054] Tissue Harvest, hESC Isolation, and Culture

[0055] IRB approval from CEIC Ethics Committee of Hospital La Fe, ValenciaSpain (code 2011 / 0383) was obtained on August 8, 2011 and each patient signed an informed consent prior to tissue collection. Severe preeclampsia (sPE) endometrial biopsies (n=13) were obtained from women with sPE during their last pregnancy (occurring between 1 and 5 years). Non-preeclamptic (non-PE) endometrial biopsies were collected from normal pregnant women (n=13) aged 18-32 years. All patients had regular menstrual cycles, had no underlying endometrial pathology, and had not received hormone therapy within 3 months prior to biopsy collection. The mean age and mean BMI were similar in both groups.

[0056]Endometrial biopsies were obtained under sterile conditions using a pipelle...

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Abstract

The invention provides non-invasive assays to reliably identify women who have or are predisposed to developing preeclampsia (PE). The method comprises measuring a level of annexin A2 (ANXA2) in a test sample obtained of a subject; and identifying the subject as having preeclampsia or at an increased risk of developing preeclampsia when the level of ANXA2 in the test sample is decreased in relation to a control sample. Methods to treat subject identified as having PE or at an increased risk of developing preeclampsia are also provided.

Description

[0001] related application [0002] This application claims the benefit of U.S. Provisional Application Serial No. 61 / 968,728, filed March 21, 2014, and U.S. Provisional Application Serial No. 61 / 969,520, filed March 24, 2014, under 35 U.S.C. § 119(e), Its content is incorporated herein by reference in its entirety. technical field [0003] The present invention generally relates to biomarkers of preeclampsia and methods for treating the disease. Background technique [0004] Preeclampsia (PE) is the leading cause of maternal and fetal morbidity and mortality, affecting 4% to 8% of pregnancies, resulting in more than 8 million cases per year worldwide. Clinically, preeclampsia is defined by the presence of hypertension, proteinuria, edema, and, in some patients, HELLP syndrome and eclampsia. Significant efforts have been made to develop markers that can accurately predict preeclampsia. Biochemical markers and Doppler ultrasound measurement of blood flow in maternal uterin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/689G01N2800/368A61K31/727A61P15/00G01N2333/47
Inventor 卡洛斯·西蒙塔玛拉·加里多安东尼奥·佩利塞尔
Owner IGENOMIX SL
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