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Preparation method of veterinary sodium ceftiofur

The technology of ceftiofur sodium and ceftiofur hydrochloride is applied in the field of preparation of veterinary ceftiofur sodium, which can solve the problems of low technical threshold, difficulty in achieving effective blood drug concentration, etc., and achieves improved drug value and low cost , the effect of simple preparation process

Inactive Publication Date: 2017-05-10
CHONGQING HONGQIAN AGRI DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are also many defects in these patents. The technical thresholds of the aforementioned three patents are relatively low, and it is easy for those skilled in the art to break through. The last patent is due to the very slow metabolism of benzylethylenediamine ceftiofur. The disadvantage is that it is difficult to achieve effective blood drug concentration in a short time, so further optimization and improvement are needed

Method used

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  • Preparation method of veterinary sodium ceftiofur

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Embodiment Construction

[0016] The present invention will be described in detail below in combination with preparation examples and pharmacodynamic examples.

[0017] Preparation Example

[0018] The preparation method of veterinary ceftiofur sodium of the present invention comprises the following steps:

[0019] (1) Add 1 mol (560 g) of ceftiofur hydrochloride into 2240 ml of tetrahydrofuran and stir thoroughly; then add 224 ml of water for injection and fully stir to obtain solution A;

[0020] (2) In solution A, add 0.5mol (20.15g) gradually and the sodium oxide superfine powder that particle size is 150 microns, stir while adding, react to obtain solution B, promptly contain product veterinary ceftiofur sodium in solution B ;

[0021] (3) filter solution B, get upper layer solution C 2000mL; add the carbon tetrachloride that is equal to the volume of upper layer solution C and fully extract solution C, obtain extraction solution 2000mL;

[0022] (4) Evaporate the extract to dryness at 37° C. a...

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Abstract

The invention relates to a preparation method of veterinary sodium ceftiofur and belongs to the field of specific treatment activities of compounds or pharmaceutic preparations; veterinary sodium ceftiofur is prepared herein by using ceftiofur hydrochloride and medicinal sodium oxide. The veterinary sodium ceftiofur is as antibacterially active as ceftiofur hydrochloride, has antibiotic properties, can supply sodium ions to a body, and has improved medicinal value; the preparation process is simple, low in cost and suitable for industrial production.

Description

technical field [0001] The invention relates to a preparation method of veterinary ceftiofur sodium, which belongs to the field of specific therapeutic activity of compounds or pharmaceutical preparations. Background technique [0002] Ceftiofur is the first third-generation cephalosporin antibiotic synthesized in the 1980s for use in animals. It has broad-spectrum and potent antibacterial effects on both Gram-positive and Gram-negative bacteria. Ceftiofur is a semi-synthetic antibiotic, which is mainly made into sodium salt freeze-dried powder and hydrochloride suspension to treat animal bacterial diseases. At present, the ceftiofur preparations reported in the market and literature include ceftiofur hydrochloride suspension injection, ceftiofur sodium powder injection or freeze-dried powder injection, ceftiofur crystal suspension injection and ceftiofur dibenzyl ethyl Diamine salt preparations. The above-mentioned preparations have been proved to be safe, efficient and s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61K33/00A61P31/04
CPCA61K31/546A61K33/00
Inventor 钟年伟
Owner CHONGQING HONGQIAN AGRI DEV CO LTD
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