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Glabridin nanosuspension and preparation method thereof

A technology of nano-suspension and glabridin, which is applied in the field of beauty and skin care cosmetics, can solve the problems of low solubility, unsatisfactory transdermal absorption effect, and limitations, and achieve the effect of simple process, accurate dosage, and reduced usage

Inactive Publication Date: 2017-05-10
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, glabridin is insoluble in water, and its solubility in liquid oil is low. In practical application, its transdermal absorption effect is not ideal, so the effect is often limited.

Method used

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  • Glabridin nanosuspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Add 0.8 g of glabridin into 80 ml of aqueous solution containing 0.4 g of Tween 80 under stirring, and ultrasonicate at 500 W for 30 seconds to form a rough suspension of glabridin. Transfer the glabridin crude suspension to a pre-cooled high-pressure homogenizer at 0-5°C for homogenization, first cycle 5 times at 500 bar, and then cycle 15 times at 1300 bar to obtain glabridin nano-suspension , The average particle diameter of the nanosuspension was measured to be 342nm. Particle size distribution as figure 1 As shown, it shows that the particle size distribution range is uniform.

Embodiment 2

[0022] Add 1 g of glabridin into 100 ml of aqueous solution containing 0.5 g of poloxamer 188 under stirring, and ultrasonicate at 500 W for 30 seconds to form a coarse suspension of glabridin. Transfer the glabridin crude suspension to a pre-cooled high-pressure homogenizer at 0-5°C for homogenization, first cycle 5 times at 500 bar, and then cycle 15 times at 1300 bar to obtain glabridin nano-suspension , The average particle diameter of the nanosuspension was measured to be 395nm.

Embodiment 3

[0024] Add 2 g of glabridin into 50 ml of aqueous solution containing 0.1 g of sodium lauryl sulfate under stirring, and ultrasonicate at 500 W for 30 seconds to form a rough suspension of glabridin. Transfer the glabridin crude suspension to a pre-cooled high-pressure homogenizer at 0-5°C for homogenization, first circulate 5 times at 500 bar, and then circulate 12 times at 1400 bar to obtain glabridin nano-suspension , The average particle diameter of the nanosuspension was measured to be 591nm.

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Abstract

The invention relates to a glabridin nanosuspension and a preparation method thereof. The formulation of the glabridin nanosuspension comprises the following ingredients by weight percentage: 0.5-20% of glabridin, 0.1-20% of a stabilizer and the balance of water. The glabridin nanosuspension is prepared by adopting ultrasonic pre-dispersion in combination with a high-pressure homogenization method. According to the glabridin nanosuspension disclosed by the invention, the solubility of the glabridin is greatly improved, the service efficiency is improved, the dosage of the glabridin in cosmetics is decreased, and the production cost is reduced.

Description

technical field [0001] The invention relates to the technical field of beauty and skin care cosmetics, in particular to a glabridin nano-suspension and a preparation method thereof. Background technique [0002] Glabridin is one of the main flavonoids in Glycyrrhizae glabra, and it is the main functional ingredient of high-end whitening cosmetics in the world. It can penetrate deep into the skin and maintain high activity, whitening and anti-oxidation. Effectively inhibit the activity of various enzymes in the process of melanin production, especially the activity of tyrosinase. At the same time, it also has the effect of preventing rough skin, anti-inflammation and antibacterial. Glabridin is currently a whitening ingredient with good curative effect and comprehensive functions. It has been proved by the laboratory that the whitening effect of glabridin is 232 times higher than that of vitamin C, a common whitening ingredient, and it is therefore highly sought after by p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K8/04A61K8/86A61K8/46A61K8/63A61K8/73A61K8/81A61Q19/00A61Q19/02A61Q19/08A61Q17/00
CPCA61Q17/005A61Q19/00A61Q19/02A61Q19/08A61K8/044A61K8/463A61K8/466A61K8/498A61K8/4993A61K8/63A61K8/731A61K8/8176A61K8/86
Inventor 刘涛姚贵丽左希敏
Owner QINGDAO UNIV OF SCI & TECH
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