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Application of GS-9620

A 1. GS-9620, immune cell technology, applied in the field of medicine, to achieve the effect of reducing secretion, reducing body damage, and reducing pathological damage

Active Publication Date: 2017-04-19
INST OF LAB ANIMAL SCI CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, the GS-9620 drug experiment is only aimed at hepatitis B virus, and there is no research showing that GS-9620 can be used to prevent and treat hand, foot and mouth disease

Method used

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  • Application of GS-9620
  • Application of GS-9620
  • Application of GS-9620

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 10-day-old ICR mice were randomly selected and randomly divided into four groups (A, B, C, D), with 10 mice in each group; each mouse was infected with MP10 (EV71 mouse-adapted strain) 1*10 7 TCID 50 . Two hours later, group A was orally administered 100 μL of normal saline; group B was orally administered GS-96200.5mg / kg; group C was orally administered GS-96201.5mg / kg; group D was orally administered GS-96204.5mg / kg. Oral administration of normal saline and GS-9620 for three consecutive days, starting from the first day of virus infection, weighing, and observing symptoms until the 10th day.

[0040] Clinical symptom scoring criteria: 0 points: no symptoms; 1 point: piloerection, arched back or decreased active movement; 2 points: slow movement of both hind limbs; 3 points: paralysis of one hind limb; 4 points: paralysis of both hind limbs; 5 points: Dead or near death.

[0041] The experimental results are shown in Table 1 and figure 1 :

[0042] Table 1 Experim...

Embodiment 2

[0047] 10-day-old ICR mice were randomly selected and randomly divided into three groups (A, B, C), with 18 mice in each group; each of groups B and C was infected with MP101*10 7 TCID 50Two hours later, groups A and B were given 100ul normal saline orally; group C was given GS-9620 4.5mg / kg; for 3 consecutive days, after 72 hours of virus infection, serum was taken for cytokine detection; Pathological detection and virus detection were carried out in formalin and Trizol; the spleen was taken and grinded for detection of immune cells;

[0048] The viral load was detected by real-time PCR method, and the results showed:

[0049] Table 2: Viral load

[0050] Muscle (pfu / g) Group A 0 Group B 2.38×10 7 ±0.913×10 7

Group C 0.64×10 7 ±0.132×10 7 ***

[0051] Note: * indicates that there is a significant difference compared with group B, p<0.05;

[0052] The results showed that: the viral load of group C was significantly lower than that of ...

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Abstract

The invention relates to the technical field of medicines, in particular to an application of GS-9620. Experiments prove that the GS-9620 can effectively inhibit replication of EV71 viruses, reduce the death rate of infected mice, improve clinical symptoms of the infected mice and relieve pathological injuries of muscles. The GS-9620, by inhibiting NK cells and macrophages, can inhibit secretion of various cytokines and reduce injury of a body caused by cytokine storm; therefore, an effect of treating hand-foot-and-mouth disease or herpangina caused by the EV71 viruses can be achieved effectively and safely.

Description

[0001] This application claims the priority of the Chinese patent application with the application number 201610940170.7 and the title of the invention "Use of GS-9620" filed with the China Patent Office on October 25, 2016, the entire contents of which are incorporated herein by reference. technical field [0002] The invention relates to the technical field of medicine, in particular to the application of GS-9620. Background technique [0003] Hand, foot and mouth disease is an infectious disease caused by enteroviruses. There are more than 20 types of enteroviruses that cause hand, foot and mouth disease, among which Coxsackie virus A16 (Cox A16) and enterovirus 71 (EV71) most common. It mostly occurs in children under 5 years old, manifested as mouth pain, anorexia, low fever, small herpes or small ulcers in hands, feet, mouth and other parts. Complications such as meningoencephalitis. Individual critically ill children develop rapidly and lead to death. At present, t...

Claims

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Application Information

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IPC IPC(8): A61K31/519A61P31/14A61P37/06A61P21/00A61P29/00A61P11/04
CPCA61K31/519
Inventor 秦川张倩刘江宁武婧李光超
Owner INST OF LAB ANIMAL SCI CHINESE ACAD OF MEDICAL SCI
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