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Use of compounds in combating post-traumatic stress disorder

A post-traumatic stress and compound technology, applied in the field of medicine, can solve the problems of delayed onset of action and low efficacy

Active Publication Date: 2019-07-16
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, the first-line drugs for the treatment of PTSD are antidepressants represented by 5-HT reuptake inhibitors (SSRIs). The only drugs approved by the US FDA for the treatment of PTSD are SSRIs such as sertraline and paroxetine. Unfortunately, these drugs There are problems such as low effective rate, delayed onset of effect (more than 2-4 weeks) and serious adverse reactions, which limit its clinical application

Method used

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  • Use of compounds in combating post-traumatic stress disorder
  • Use of compounds in combating post-traumatic stress disorder
  • Use of compounds in combating post-traumatic stress disorder

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Embodiment Construction

[0057] As used in the present invention, the term "halogen" refers to fluorine, chlorine, bromine, iodine.

[0058] As used in the present invention, the term "C 1 -C 6 Alkyl"refers to a linear or branched alkyl group containing 1-6 carbon atoms, such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert Butyl, n-pentyl, isopentyl, 2-methylbutyl, neopentyl, 1-ethylpropyl, n-hexyl, isohexyl, 3-methylpentyl, 2-methylpentyl, 1 -Methylpentyl, 3,3-dimethylbutyl, 2,2-dimethylbutyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3- Dimethylbutyl, 2,3-dimethylbutyl, 2-ethylbutyl, 1,2-dimethylpropyl, etc. C 1 -C 6 Preferred examples of alkyl include C 1 -C 4 alkyl. The "C" described in the present invention 1 -C 4 "Alkyl" means a linear or branched alkyl group containing 1-4 carbon atoms, including but not limited to the specific examples containing 1-4 carbon atoms in the above examples.

[0059] As used in the present invention, the term "C 1 -C 6 Alkoxy" ref...

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Abstract

The invention relates to an application of a compound in resisting post-traumatic stress disorders, in particular to an application of a compound as shown in Formula I (shown as Description), or a tautomer, a racemate, an optical isomer or pharmaceutical salt of the compound in preparing a medicine for preventing or treating the post-traumatic stress disorders. The compound provided by the invention has a significant effect on the post-traumatic stress disorders, and the compound has the advantages of being rapid to take effects, free from sexual dysfunction and the like.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the application of compounds in anti-post-traumatic stress disorder, in particular to the application of 1-(4-hydroxypiperidine-4-methyl)-piperidin-2(1H)-one derivatives in anti-traumatic Use in post stress disorder. Background technique [0002] Posttraumatic stress disorder (PTSD) refers to a delayed and long-lasting mental disorder after an individual encounters an unusual threat or disaster. In recent years, with severe natural disasters, major infectious disease epidemics, Emergencies continue to occur, and PTSD has become a major disease that endangers human health. [0003] At present, the first-line drugs for the treatment of PTSD are antidepressants represented by 5-HT reuptake inhibitors (SSRIs). The only drugs approved by the US FDA for the treatment of PTSD are SSRIs such as sertraline and paroxetine. Unfortunately, these drugs There are problems such as low effective rate, del...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4545A61P25/00A61P25/18A61P25/28
CPCA61K31/4545
Inventor 李云峰杨日芳张黎明孙立君张有志薛瑞
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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