Cholelithiasis related blood plasma metabolism micro-molecular marker and application thereof
A technology for metabolic small molecules and markers, applied in the field of detecting metabolic small molecule markers related to the occurrence of cholelithiasis, can solve the problems of complex experimental steps and low sensitivity, and achieve improved sensitivity and specificity, high sensitivity and specificity. the effect of slowing down the progression of the disease
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[0084] Study object selection and grouping basis
[0085] The present invention collected the blood of cholelithiasis and normal non-cholelithiasis individuals meeting the requirements from the Cholelithiasis Center of Shanghai Dongfang Hospital Affiliated to Tongji University from July 2011 to June 2012 ( Figure 1A and Figure 1B : for gallbladder stones seen by ultrasound and naked eyes), through sorting out the sample data, 200 cases of healthy controls (average age: 45.1±6.3 years old), 200 cases of cholelithiasis patients (average age: 46.5±6.3 years old) and 200 cases of cholelithiasis patients (average age: 5.2 days) as a screening test object for cholelithiasis metabolic small molecule biomarkers. Specific sample classification standards are as follows: specific sample classification
[0086] The class standards are as follows:
[0087] Group A: healthy control group (n=100, 75 people screened, 25 people verified by independent population):
[0088] 1. Age 25-70 ye...
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