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Lacosamide oral solution and preparation method thereof

A technology of lacosamide and oral solution, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, organic active ingredients, etc., and can solve problems such as unseen production

Inactive Publication Date: 2017-04-05
BEIJING VENTUREPHARM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are registration declarations for raw materials, tablets, syrups and injections in China, but no production has been seen yet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] .

[0022] Preparation:

[0023] (1) Add the raw drug lacosamide and glycerin with 20% water, heat to dissolve, and set aside;

[0024] (2) Dissolve sorbitol, ethylparaben, citric acid, menthol, and acesulfame potassium in 60% water under heating conditions, stir and dissolve, and add sodium carboxymethylcellulose when the temperature drops to 40-50°C , stir to dissolve, set aside;

[0025] (3) Add (1) into (2), stir well, add hydrochloric acid (sodium hydroxide solution) regulator to pH 4.0-6.0, stir evenly, add water to 1000ml, and get ready.

Embodiment 2

[0027] .

[0028] Preparation:

[0029] (1) Add the raw drug lacosamide and glycerin with 20% water, heat to dissolve, and set aside;

[0030] (2) Dissolve sodium saccharin, methylparaben, propylparaben, citric acid, and essence in 60% water under heating and stir to dissolve, and add sodium carboxymethylcellulose when the temperature drops to 40-50°C , stir to dissolve, set aside;

[0031] (3) Add (1) into (2), stir well, add hydrochloric acid (sodium hydroxide solution) regulator to pH 4.0-6.0, stir evenly, add water to 1000ml, and get ready.

Embodiment 3

[0033] .

[0034] Preparation:

[0035] (1) Add the raw material lacosamide and propylene glycol with 20% water, heat to dissolve, and set aside;

[0036] (2) Dissolve sodium saccharin, ethylparaben, citric acid, and essence in 60% water under heating conditions and stir to dissolve. When the temperature drops to 40-50°C, add tragacanth gum, stir to dissolve, and set aside;

[0037] (3) Add (1) into (2), stir well, add hydrochloric acid (sodium hydroxide solution) regulator to pH 4.0-6.0, stir evenly, add water to 1000ml, and get ready.

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PUM

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Abstract

The invention discloses a lacosamide oral solution and a preparation method of the lacosamide oral solution and belongs to the field of pharmaceutical preparations. The lacosamide oral solution comprises lacosamide, an appropriate medicine solvent system, one or more flavoring agents, one or more preservatives, one or more acid-base modifiers, one or more solubilizers and one or more thickeners. The lacosamide oral solution is stable in performance, good in taste, rapid in absorption, capable of acting rapidly and good in curative effect.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations. Background technique [0002] Lacosamide is a novel NMDA receptor glycine site-binding antagonist, which belongs to a new class of functional amino acids and is an anticonvulsant drug with a new dual mechanism of action. Lacosamide is used in combination with first- and second-generation antiepileptic drugs to improve epilepsy control. It selectively promotes the slow inactivation of sodium channels and regulates collapse response mediator protein-2 (CRMP-2), which may delay or even block epileptic seizures and alleviate diabetic neuropathic pain. [0003] Epilepsy is a common neurological disorder affecting approximately 500,000 people worldwide. Central nervous system (CNS) drugs have always been a relatively active area of ​​development. Among them, the average annual growth rate of antiepileptic drugs in the international market is about 10%, ranking third in the growth rate of ce...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/165A61K47/38A61K47/36A61P25/08
CPCA61K9/0053A61K9/08A61K31/165A61K47/36A61K47/38
Inventor 马莉王宇杰
Owner BEIJING VENTUREPHARM BIOTECH
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