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A method for diagnosing tuberculous meningitis

A tuberculous meningitis and biomarker technology, applied in biochemical equipment and methods, microbiological measurement/testing, material inspection products, etc., can solve problems such as weak diagnostic ability

Inactive Publication Date: 2017-02-22
STELLENBOSCH UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There have been many attempts to develop simplified TB tests, mainly antigen tests, but their diagnostic power remains poor

Method used

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  • A method for diagnosing tuberculous meningitis
  • A method for diagnosing tuberculous meningitis
  • A method for diagnosing tuberculous meningitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0056] method

[0057] Study Population and Case Definitions

[0058] A cohort study of children aged 3 months to 13 years with symptoms and features of suspected meningitis admitted between November 2012 and November 2009 at Tygerberg Hospital in Cape Town, South Africa. Symptoms and features of meningitis include one or more of the following: headache, restlessness, vomiting, fever, neck stiffness, convulsions, focal neurologic deficits, altered consciousness, or lethargy. According to Marais et al. [7] Using documented diagnostic criteria, all children with suspected meningitis were retrospectively classified into TBM or non-TBM groups.

[0059] Microbiological evaluation of CSF

[0060] In patients with suspected TBM, direct fluorescence microscope auramine staining technique, BACTEC MGIT 960 (Becton Dickinson Diagnostic Systems, USA) culture and two commercially available nucleic acid amplification tests, GenoTypeMTBDRplus (Hain Life Sciences, Nelen, Germany) and Gene...

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Abstract

A method for diagnosing tuberculous meningitis (TBM) is described herein. A fluid sample from a subject suspected of having TBM is tested for the presence of at least two of Interleukin-13 (IL-13), Vascular endothelial growth factor (VEGF), Cathelicidin (LL-37), IL- 7, IL-12p70, IFN-gamma, IL-6, IL-10, IL-13, IP-10, MIP-1a, MIP-1b, RANTES and GM-CSF. Increased levels of at least any two of these biomarkers in the sample compared to levels in subjects without TBM are indicative that the subject has TBM.

Description

[0001] Cross References to Related Applications [0002] This application claims priority from South African Provisional Patent Application 2014 / 02743, which is hereby incorporated by reference. technical field [0003] The invention relates to a method for diagnosing tuberculous meningitis. [0004] technical background [0005] Currently, one-third of the world's population is infected with Mycobacterium (M.) tuberculosis, and more than 15 million people die from the resulting disease each year [1]. Involvement of the central nervous system (CNS) accounts for 1 percent of all pulmonary tuberculosis cases, with tuberculous meningitis (TBM) being the most severe case and often occurring in early childhood [2]. [0006] Hematogenous transmission of bacilli from primary pulmonary lesions may result in caseating granulomas in the meninges, brain tissue adjacent to the meninges, or ependyma, so-called Rich focuses. Rupture of this Rich lesion in the subretinal space results in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/569C12Q1/68C12Q1/04
CPCG01N33/6863G01N2333/35G01N2333/4721G01N2333/475G01N2333/5437
Inventor 诺韦尔·恩基威彼·齐格欧格哈德·瓦兹拉安妮·马瑟琳·万福斯杜威·亨德里克·维瑟
Owner STELLENBOSCH UNIVERSITY
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