PET (positron emission computed tomography)-fluorescence dual-mode intraoperative navigation imaging system and imaging method implemented by same

Abstract

The invention discloses a PET (positron emission computed tomography)-fluorescence dual-mode intraoperative navigation imaging system and an imaging method implemented by the same. The imaging method includes forming three-dimensional surface contour images of imaging samples by the aid of a spatial registration device; acquiring three-dimensional PET images of internal structures of the imaging samples by the aid of a PET imaging device; carrying out image registration and fusion on the three-dimensional surface contour images and the three-dimensional PET images to obtain three-dimensional fused images of imaging targets; acquiring two-dimensional fluorescence images of the imaging samples in real time by the aid of a fluorescence imaging device; projecting the three-dimensional fused images towards the two-dimensional fluorescence images along the normal axis of an imaging surface of the fluorescence imaging device and displaying depth information of the imaging targets on the two-dimensional fluorescence images. The three-dimensional fused images of the imaging targets comprise surface contours and internal structures. The PET-fluorescence dual-mode intraoperative navigation imaging system and the imaging method have the advantages that the PET-fluorescence dual-mode intraoperative navigation imaging system and the imaging method can be applied to tumor operation, the three-dimensional PET images and the two-dimensional fluorescence images are fused in computers, two imaging modes are complementary to each other, accordingly, tumor at optional depths can be accurately positioned, accurate tumor location information can be provided for patients, and tumor R0-resection can be implemented.

Description

technical field [0001] The invention relates to the field of biomedical imaging, in particular to a PET-fluorescence dual-mode intraoperative navigation imaging system and an imaging method thereof. Background technique [0002] At present, surgical treatment is the main treatment for most tumors. About 90% of tumors use surgery as a tool for diagnosis and staging. The postoperative survival period and quality of life of patients are closely related to the completeness of surgical resection. As early as 2003, Professor John V. Frangioni of Harvard Medical School in the United States published a paper on J.Biomed.Opt, pointing out that there is a lack of imaging equipment suitable for surgeons in cancer surgery. Until now, most surgeons still can only make judgments based on the shape of the tumor, histopathological features and personal experience during the operation, and cannot make an objective and accurate diagnosis on the size, border and whether the tumor is completely...

AI Technical Summary

Problems solved by technology

Most research on PET surgical navigation focuses on how to quickly fuse preoperative PET images and intraoperative computerized tomography CT images to achieve PET / CT on-the-spot registration, but this technology is limited by the surgical part of the patient during the operation. The change of the position of the positron (β+) nuclides can only be guided at the initial stage of the operation, and cannot be guided in real time during the operation; in addition, scientists in the Netherlands and Switzerland used gamma detectors to count and measure positron (β+) nuclides as a method for real-time tumor resection during the operation. However, due to the poor positioning of the tumor site by this technology, the auxiliary effect on the doctor during the operation is limited, and the subsequent further promotion is also limited.

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