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Preparation technology of wall-breaking decoction piece

A technology of broken-wall decoction pieces and preparation process, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, plant raw materials, etc., which can solve the problems of rapid dissolution of unfavorable medicinal active ingredients, inability to form ultrafine powder, and poor stability and other problems to achieve the effect of avoiding screen blockage, moderate tightness and good formability

Inactive Publication Date: 2017-02-01
云南瑞药金方现代中药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] According to the current preparation process, the prepared broken-walled decoction pieces are not only fast, but also have small particles, which are difficult to dissolve during actual use, which is not conducive to the rapid dissolution of medicinal ingredients
In addition, there are still some deficiencies in the molding of the particles of the current broken-walled decoction pieces, and some superfine powders cannot even be molded, and the stability is relatively poor

Method used

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  • Preparation technology of wall-breaking decoction piece
  • Preparation technology of wall-breaking decoction piece
  • Preparation technology of wall-breaking decoction piece

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Coix Seed Broken Wall Decoction Pieces

[0037] 1) Medicinal material processing: the coix seed medicinal material is sorted, cleaned, dried, sliced, and coarsely crushed to about 100 mesh;

[0038] 2) Intermittent sterilization: Coix seed coarse powder is placed in a constant temperature and humidity box with a thickness of about 10mm, set at a temperature of 65°C (the actual temperature is 60-70°C), and kept dry and sterilized for 8 hours; The powder is maintained at a temperature of 25°C and a relative humidity of 75% for 12 hours; then the temperature of the constant temperature and humidity box is adjusted to 35°C and the relative humidity is 88% for 24 hours; 30mm, set the temperature at 75°C (the actual temperature is 70-80°C), keep it dry and sterilized for 4 hours; routinely detect the microorganisms in the coarse powder of medicinal materials, and obtain the coarse powder of coix seed that meets the microbial limit requirements for direct consumption of decoctio...

Embodiment 2

[0044] Coix Seed Broken Wall Decoction Pieces

[0045] 1) Medicinal material processing: the coix seed medicinal material is sorted, cleaned, dried, sliced, and coarsely crushed to about 100 mesh;

[0046] 2) Bacteria-killing process: Coix seed coarse powder is placed in a constant temperature and humidity box with a thickness of about 5mm, set at a temperature of 70°C (the actual temperature is 65-75°C), and kept dry and sterilized for 4 hours; The powder is maintained at a temperature of 20°C and a relative humidity of 70% for 15 hours; then the temperature of the constant temperature and humidity box is adjusted to 33°C and the relative humidity is 83% for 8 hours; 20mm, set the temperature at 65°C (the actual temperature is 60-70°C), keep it dry and sterilized for 6 hours; repeat the steps of dormant body growth-killing the vegetative body once again, and routinely detect the microorganisms in the coarse powder of medicinal materials; Directly take Coix seed coarse powder...

Embodiment 3

[0052] Cinnamon Broken Drink Pieces

[0053] 1) Medicinal material processing: the cinnamon medicinal material is sorted, cleaned, dried, sliced, and coarsely crushed to about 100 mesh;

[0054] 2) Bacteria-killing process: Put the coarse cinnamon powder in a constant temperature and humidity box with a thickness of about 30mm, set the temperature at 75°C (the actual temperature is 70-80°C), and keep it dry and sterilized for 4 hours; the coarse powder of medicinal materials after treatment Maintain at a temperature of 25°C and a relative humidity of 75% for 24 hours; then adjust the temperature of the constant temperature and humidity box to 40°C and maintain a relative humidity of 80% for 12 hours; place the coarse powder of medicinal materials in a constant temperature and humidity box with a thickness of 10mm , set the temperature at 80°C (the actual temperature is 75-85°C), keep it dry and sterilized for 0.5h; repeat the steps 4 times, and routinely detect the microorgani...

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Abstract

The invention provides a preparation technology of a wall-breaking decoction piece. A soft material is prepared by adopting and adding partial auxiliary materials, and then the soft material is palletized, so that obtained granules are relatively good in grain shapes, moderate in degree of tightness, good in formability and relatively high in stability; moreover, the prepared granules are dried relatively easily, dissolved relatively quickly and dispersed easily when being taken by a user, so that the problem that wall-breaking decoction pieces on the market are difficult to dissolve and poor in stability and formability at present is solved.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine treatment, in particular to a preparation process of broken-wall decoction pieces. Background technique [0002] Ultrafine pulverization technology is a new technology developed rapidly in recent years. Most of the active ingredients in Chinese herbal medicines are distributed in the cells. When decocting conventional decoction pieces, only part of the active ingredients can be released. About 86.7% of the cell wall breaking rate will improve the dissolution of the active ingredients in the medicinal materials, greatly enhance its efficacy, and the utilization rate of the active ingredients will be above 90%, so as to reduce the amount of medicinal materials used and protect the medicinal materials resources. The quality increases the efficacy. Due to the increased cell wall breaking rate of ultrafine preparations, there are inherent characteristics such as increased surface...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61K36/54A61K36/00A61K9/16A61K47/46A61K47/36A61K47/32A61L2/04A61L2/07
CPCA61K36/8994A61K9/1635A61K9/1652A61K9/1664A61K36/00A61K36/54A61K2236/13A61K2236/15A61L2/0023A61L2202/21
Inventor 杨记宗王娜关建雄罗铭中朱瑞清
Owner 云南瑞药金方现代中药有限公司
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