Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Silicified microcrystalline cellulose and preparation method thereof

A technology of microcrystalline cellulose and silicification, which is used in pharmaceutical formulations, medical preparations with non-active ingredients, and pill delivery. , good fluidity and compressibility, simple process effect

Active Publication Date: 2017-01-18
HUZHOU ZHANWANG PHARMA
View PDF4 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are not many technical literatures on the research and large-scale production of silicified microcrystalline cellulose in China at present.
The paper "Evaluation of Fluidity of Silicified Microcrystalline Cellulose Powder" published in Volume 44, No. 5 of the Journal of "China Pharmaceutical University" in 2013 affirmed the good fluidity and compressibility of Silicified Microcrystalline Cellulose, which can meet the requirements of pharmaceuticals. The requirement for direct tablet compression with excipients, but no specific production process for the silicified microcrystalline cellulose
However, in the preparation method disclosed in the patent CN104771761A, the solid content of the slurry formulated with microcrystalline cellulose and micropowder silica gel is only 0.5%-4.8%. Too low solid content leads to very low yield, which does not have actual industrial value, and the method The micropowder silica gel used is expensive, and the bulk density and particle size distribution of the prepared silicified microcrystalline cellulose are wide and uneven

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Silicified microcrystalline cellulose and preparation method thereof
  • Silicified microcrystalline cellulose and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] First dilute 100g of acidic silica sol with an average particle size of 15nm and a silica content of 25% (produced by one-step dissolution of simple silicon, the same below) with pure water, and then add 2500g of silica sol with a water content of 55% to the diluted silica sol % of microcrystalline cellulose wet material, homogenized and filtered to obtain a slurry with a mass concentration of microcrystalline cellulose of 13%, a proportion of silicon dioxide in the total dry matter of 2.2%, and a conductivity of 23 μS / cm.

[0031] Finally, the slurry is dried by air-flow two-fluid spraying and then sieved to obtain silicified microcrystalline cellulose with a bulk density of 0.31 g / ml and a particle size of 40-60 μm. The air inlet temperature of the air-flow two-fluid spray drying is 160°C, the outlet air temperature is 85°C, the compressed air pressure is 0.4MPa, and the speed of the peristaltic pump that transports the slurry to the atomizing nozzle is 45r / min.

[00...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Bulk densityaaaaaaaaaa
Particle sizeaaaaaaaaaa
The average particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention relates to silicified microcrystalline cellulose and a preparation method thereof. The preparation method comprises the following specific steps: diluting silica sol with pure water, adding a microcrystalline cellulose wet material into the diluted silica sol, performing homogenization, filtering to obtain slurry, finally performing spray drying on the slurry through air flow type double fluids, and screening to prepare the silicified microcrystalline cellulose. The bulk density and the particle size of the silicified microcrystalline cellulose are uniform, and the silicified microcrystalline cellulose is high in flowability and compressibility; as a medicinal auxiliary material, the silicified microcrystalline cellulose has the outstanding effect on direct tabletting. The preparation method of the silicified microcrystalline cellulose is simple in technology, short in process and low in cost, and the yield can meet the requirement on industrial production.

Description

technical field [0001] The invention relates to silicified microcrystalline cellulose and a preparation method thereof, belonging to the field of medicine and chemical industry. Background technique [0002] Silicified microcrystalline cellulose is prepared from microcrystalline cellulose and silicon dioxide. Its fluidity is comparable to that of coarse-grained microcrystalline cellulose, but its surface area is five times that of microcrystalline cellulose, and its compressibility is increased by 30-50. %, which can meet the demand for direct compression of pharmaceutical excipients. However, there are not many technical literatures on the research and large-scale production of silicified microcrystalline cellulose in China. The paper "Evaluation of Fluidity of Silicified Microcrystalline Cellulose Powder" published in Volume 44, No. 5 of the Journal of "China Pharmaceutical University" in 2013 affirmed the good fluidity and compressibility of Silicified Microcrystalline C...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/20A61K47/38A61K47/04
CPCA61K9/2009A61K9/2054
Inventor 臧月龙陈颖潘继成郭海英
Owner HUZHOU ZHANWANG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com