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Extraction method of astragalus polysaccharide and preparation method of veterinary astragalus polysaccharide oral liquid

A technology of astragalus polysaccharide and extraction method, which is applied in the field of extraction of astragalus polysaccharide and preparation of astragalus polysaccharide oral liquid for veterinary use, can solve the problem that the yield and purity of polysaccharide cannot be kept at a high level at the same time, and achieve the convenience of subsequent separation and extraction temperature Low, cost-saving effect

Active Publication Date: 2019-06-28
ZHENGZHOU FUYUAN ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method can increase the yield of astragalus polysaccharides to more than 20%, and at the same time, the purity is more than 80%, which solves the problem that the yield and purity of polysaccharides cannot be kept at a high level at the same time to a certain extent, but there is still room for further improvement

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  • Extraction method of astragalus polysaccharide and preparation method of veterinary astragalus polysaccharide oral liquid
  • Extraction method of astragalus polysaccharide and preparation method of veterinary astragalus polysaccharide oral liquid
  • Extraction method of astragalus polysaccharide and preparation method of veterinary astragalus polysaccharide oral liquid

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Embodiment 1

[0041] The extraction method of astragalus polysaccharide comprises the following steps:

[0042] 1) Grinding the Radix Astragali with an ultrafine pulverizer to a particle size of 5-8 μm to obtain Radix Astragali powder;

[0043] 2) Using the flash extraction method, add calcium oxide aqueous solution (pH 9.0) with a concentration of 0.1‰ to the astragalus powder, add 8mL calcium oxide aqueous solution to each gram of astragalus powder, mix well and place it in the flash extractor, set the motor voltage to 200V , the extraction temperature is 50°C, and the extraction time is 3 minutes;

[0044] After the extraction is completed, the medicinal residues are separated, the above-mentioned extraction operation is repeated twice, and the extracts are combined for subsequent use;

[0045] 3) concentrating the extract to a relative density of 1.06 at 90°C to obtain a concentrate A;

[0046] Take the concentrated solution A, and clarify and remove impurities in two steps. The first...

Embodiment 2

[0055] The extraction method of astragalus polysaccharide comprises the following steps:

[0056] 1) Grinding the Radix Astragali with an ultrafine pulverizer to a particle size of 3-5 μm to obtain Radix Astragali powder;

[0057] 2) Using the flash extraction method, add calcium oxide aqueous solution (pH 9.5) with a concentration of 0.07‰ to the astragalus powder, add 9mL calcium oxide aqueous solution per gram of astragalus powder, mix well and place it in the flash extractor, set the motor voltage to 200V , the extraction temperature is 55°C, and the extraction time is 2.5 minutes;

[0058] After the extraction is completed, the medicinal residues are separated, the above-mentioned extraction operation is repeated 3 times, and the extracts are combined for subsequent use;

[0059] 3) concentrating the extract to a relative density of 1.07 at 90°C to obtain a concentrate A;

[0060] Take the concentrated solution A, and clarify and remove impurities in two steps. The firs...

Embodiment 3

[0069] The extraction method of astragalus polysaccharide comprises the following steps:

[0070] 1) Grinding the Radix Astragali with an ultrafine pulverizer to a particle size of 8-10 μm to obtain Radix Astragali powder;

[0071] 2) Using the flash extraction method, add calcium oxide aqueous solution (pH 10.0) with a concentration of 0.1‰ to the astragalus powder, add 10mL calcium oxide aqueous solution per gram of astragalus powder, mix well and place it in the flash extractor, set the motor voltage to 200V , the extraction temperature is 60°C, and the extraction time is 2 minutes;

[0072] After the extraction is completed, the medicinal residues are separated, the above-mentioned extraction operation is repeated twice, and the extracts are combined for subsequent use;

[0073] 3) concentrating the extract to a relative density of 1.08 at 90°C to obtain a concentrate A;

[0074] Take the concentrated solution A, and clarify and remove impurities in two steps. The first ...

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Abstract

The invention discloses an extraction method of astragalus polysaccharide and a preparation method of a veterinary astragalus polysaccharide oral liquid and belongs to the technical field of veterinary drug processing. The astragalus polysaccharide is extracted in a mode of combining superfine grinding with flash extraction, pharmaceutical extraction is sufficient and fast, the content of polysaccharide is high, and the activity is good. Meanwhile, the astragalus polysaccharide is purified in a mode of combining step-by-step clarification and impurity removal with alcohol precipitation extraction, an obtained liquid medicine is clear and pure, and impurity removal consumes short time and is high in efficiency and low in cost. The extraction process of the astragalus polysaccharide is simple, easy to operate, high in efficiency, time-saving and labor-saving in operation and low in energy consumption, the temperature of extraction and purification is low, extraction of raw medicinal materials is sufficient, and the polysaccharide is high in purity and good in activity. The astragalus polysaccharide oral liquid is high in activity and good in stability.

Description

technical field [0001] The invention relates to a method for extracting astragalus polysaccharide, and also relates to a method for preparing oral liquid of astragalus polysaccharide for animals, which belongs to the technical field of veterinary medicine processing. Background technique [0002] Astragalus membranaceus is one of the commonly used traditional Chinese medicines. It is widely used clinically. It has the effects of invigorating qi and strengthening the surface, detoxifying and discharging pus, diuretic, astringing sores and promoting granulation. Astragalus contains a variety of active ingredients, including saponins, polysaccharides, flavonoids, amino acids and trace elements. Among them, polysaccharides are a class of macromolecular compounds that play an important role in the pharmacology of Astragalus. In traditional clinical practice, Astragalus is mainly used in the form of decoction pieces or crushed and made into decoctions and pills with other Chinese...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61K31/715A61K9/08A61P37/04A61P31/16A61K36/481
CPCA61K9/0095A61K31/715A61K36/481A61K2236/333A61K2236/39A61K2236/53A61K2236/55C08B37/0003
Inventor 袁宝青赵保会薛亚军李红娇
Owner ZHENGZHOU FUYUAN ANIMAL PHARMA
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