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Blood purification therapeutic apparatus for treating mother-fetus Rh blood group incompatibility

A technology of blood purification and therapeutic equipment, which is applied in the direction of blood circulation treatment, blood filtration, and other medical devices to achieve enhanced effects, increased uniformity and surface area

Active Publication Date: 2017-01-04
ATTACHED OBSTETRICS & GYNECOLOGY OSPITAL MEDICALCOLLEGE ZHEJIANG UNIV +1
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

But so far there is no report on the design of the treatment of blood group incompatibility hemolytic disease according to the above mechanism

Method used

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  • Blood purification therapeutic apparatus for treating mother-fetus Rh blood group incompatibility
  • Blood purification therapeutic apparatus for treating mother-fetus Rh blood group incompatibility
  • Blood purification therapeutic apparatus for treating mother-fetus Rh blood group incompatibility

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Embodiment Construction

[0012] figure 1 It is a schematic diagram of the application of the blood purification treatment instrument for maternal-fetal Rh incompatibility proposed according to the present invention.

[0013] figure 2It is a schematic diagram of the internal structure of the plasma separator proposed according to the present invention.

[0014] image 3 It is a schematic diagram of the internal structure of the purifier according to the present invention

[0015] figure 1 Among them, one end of the arterial blood line tube (1) is connected with the arterial blood vessel, and the other end is connected with the plasma separator (4) through the heparin pump (2) and the blood pump (3), and the plasma separator (4) is connected through the plasma pump (6) ) and the circulation pipeline (7) are connected to two parallel purifiers (8) and purifiers (9), and then connected to the circulation pipeline (10) and the venous pipeline (5) in turn, and the venous pipeline (5) The other end is ...

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Abstract

The invention relates to a blood purification therapeutic apparatus for treating mother-fetus Rh blood group incompatibility in the medical field. The blood purification therapeutic apparatus is characterized in that PB lysates with osmotic concentrations of 25 mmol / L and 35 mmol / L respectively are prepared; rhesus red blood cells containing a common Rh antigen of human red blood cells are alternately washed to prepare ghost cells which dialyze hemoglobin but retain the Rh antigen and can effectively adsorb an Rh antibody; purifying agents with the ghost cell concentration of 95% are prepared by using agarose, with the concentrations of 0.9%, 1.0%, 1.1%, 1.2% and 1.3% respectively, molten at 100 DEG C and then thermally insulated at 42 DEG C; from high concentration to low concentration of the agarose, 55-65ml of the purifying agents are sequentially added into a cylindrical container made of a highly-biocompatible material so as to form an adsorber in which ghost cells in the purifying agents are uniformly distributed from the sample inlet end to the sample outlet end, but agarose concentration gradually increases from the sample inlet end to the sample outlet end; the adsorber is used for clearing away the Rh antibody in plasma of a filtering purifier and macromolecular pathogenic substances generated by destroyed red blood cells so as to treat a hemolytic disease caused by the Rh blood group incompatibility.

Description

technical field [0001] The invention relates to a blood purification treatment apparatus for maternal-fetal Rh incompatibility in the medical field, which is mainly used for removing anti-fetal red blood cell antibodies and red blood cell lysates in plasma of pregnant women with maternal-fetal blood group incompatibility. Background technique [0002] The fetus inherits half of the genetic components of the father and half of the mother, and the fetal red blood cells can carry antigens from the father, showing that the blood type of the fetus is different from that of the mother. When the fetal red blood cells enter the mother's blood circulation, the mother's immune system is induced to produce antibodies, and the antibodies pass through the placenta and enter the fetal blood circulation system, combining with fetal red blood cells, causing fetal red blood cells to be destroyed, resulting in maternal-fetal blood group incompatibility hemolytic disease in fetuses and newborns...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/34A61M1/36
CPCA61M1/3496A61M1/3601A61M1/3621A61M1/3693A61M2202/0429A61M2205/02A61M2210/12
Inventor 翁炳焕李兰娟
Owner ATTACHED OBSTETRICS & GYNECOLOGY OSPITAL MEDICALCOLLEGE ZHEJIANG UNIV
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