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Pharmaceutical composition for treating paraquat poisoning

A composition and drug technology, applied in the direction of drug combination, antidote, pharmaceutical formula, etc., can solve problems such as inconspicuous symptoms, easy misdiagnosis or neglect of diseases

Inactive Publication Date: 2017-01-04
刘峰亭
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the symptoms are not obvious during the golden period of treatment in the early stage of poisoning, it is easy to misdiagnose or ignore the disease

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: according to mint 17g, gecko 7g, red fungus 11g, cordyceps 1g, sealwort 14g, Gentiana 7g, capillary 17g, Qingsong 11g, Poria cocos 11g, aconite 15g, gardenia 1g, licorice 11g, rose bud root 5g The formula measures each component, and after weighing according to the stated ratio, use one-third of the mint, gecko, red fungus, and cordyceps decoction as a diluent, and the other two-thirds of mint, gecko, Red fungus, Cordyceps, Polygonatum, Gentiana, Capillary and other components are mixed, add 30 times the amount of water of the mixture, soak and decoct three times, about half an hour each time, combine the decoction three times, filter, concentrate to a paste, add Stir the mulberry liquid diluent evenly to make a soft material, dry it at 50-80°C, grind it into a fine powder, use 94% ethanol as a binder to make a 100-mesh granule, and add 3% of the granule mass after the granulation % magnesium stearate, dried and milled to make powder A.

Embodiment 2

[0029] Embodiment 2: according to mint 7g, gecko 17g, red fungus 1g, cordyceps 11g, Polygonatum 4g, Gentiana 17g, capillary 7g, Qing Song 1g, Poria 21g, aconite 5g, gardenia 11g, licorice 1g, rose bud root 15g The formula measures each component, and after weighing according to the stated ratio, use one-third of the mint, gecko, red fungus, and cordyceps decoction as a diluent, and the other two-thirds of mint, gecko, Red fungus, Cordyceps, Polygonatum, Gentiana, Capillary and other components are mixed, add 30 times the amount of water of the mixture, soak and decoct three times, about half an hour each time, combine the decoction three times, filter, concentrate to a paste, add Stir the mulberry liquid diluent evenly to make a soft material, dry it at 50-80°C, grind it into a fine powder, use 94% ethanol as a binder to make a 100-mesh granule, and add 3% of the granule mass after the granulation % magnesium stearate, dried and ground to make powder B.

Embodiment 3

[0030] Embodiment 3: according to mint 13g, gecko 11g, red fungus 7g, cordyceps 5g, Polygonatum 10g, Gentiana 11g, capillary 13g, Qing Song 7g, Poria cocos 15g, aconite 11g, gardenia 5g, licorice 7g, rose bud root 9g The formula measures each component, and after weighing according to the stated ratio, use one-third of the mint, gecko, red fungus, and cordyceps decoction as a diluent, and the other two-thirds of mint, gecko, Red fungus, Cordyceps, Polygonatum, Gentiana, Capillary and other components are mixed, add 30 times the amount of water of the mixture, soak and decoct three times, about half an hour each time, combine the decoction three times, filter, concentrate to a paste, add Stir the mulberry liquid diluent evenly to make a soft material, dry it at 50-80°C, grind it into a fine powder, use 94% ethanol as a binder to make a 100-mesh granule, and add 3% of the granule mass after the granulation % magnesium stearate, dried and milled to make powder C.

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Abstract

The invention relates to pharmaceutical composition for treating paraquat poisoning. The composition is prepared from the following components in parts by weight: 7-17 parts of mint, 7-17 parts of geckoes, 1-11 parts of iresine herbstii, 1-11 parts of caterpillar fungi, 4-14 parts of solomonseal rhizomes, 7-17 parts of largeleaf gentian roots, 7-17 parts of virgate wormwood herbs, 1-11 parts of sweet wormwood herbs, 11-21 parts of poria cocos, 5-15 parts of common monkshood daughter roots, 1-11 parts of Cape jasmine fruits, 1-11 parts of licorice roots and 5-15 parts of macartney rose roots. The drugs in the formula are compatible, monarch and minister drugs are synergetic, and adjuvant drugs and envoy drugs assist together. The pharmaceutical composition is aimed at enhancing the human immunity, improving the self-repair capacity as well as the transformation and transport function of viscera and resisting pulmonary fibrosis and peripheral viscera block finally.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating paraquat poisoning. Background technique [0002] Paraquat is an organic nitrogen heterocyclic compound, the active ingredient is 1,1 dimethyl-4,4 bipyridine cation salt, the pure product is white crystal, odorless, soluble in water, and has grammezole and paraquat Various trade names such as Kuai, Yehuo, Baiduo, and Barasha, etc., are a fast-killing herbicide with contact and certain systemic effects. It can be quickly absorbed by the green tissue of plants, causing them to die. Paraquat is extremely toxic to humans and can be absorbed through the skin and mucous membranes, respiratory tract and gastrointestinal tract. Its absorption rate and excretion rate are relatively fast, and its absorption rate in the lungs is relatively high. Oral or skin contact can cause poisoning, and the estimated lethal dose of 20% aqueous solution for adults is about 5-15ml. The poisoning phenomenon is...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61P39/02A61K35/583
CPCA61K36/8969A61K35/583A61K36/068A61K36/076A61K36/21A61K36/282A61K36/484A61K36/51A61K36/534A61K36/714A61K36/738A61K36/744A61K2236/331A61K2236/39A61K2300/00
Inventor 姬悠然刘峰亭崔宏冰崔洁王育娟
Owner 刘峰亭
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