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Tartaric acid pimavanserin oral instant film and preparation method thereof

A technology of pimavanserin and oral instant film, which is applied in the field of pimavanserin tartrate oral instant film and its preparation, can solve the problems that hallucination symptoms are unlikely to be effective, and achieve good taste, simple preparation method, and low consumption. short-term effect

Inactive Publication Date: 2017-01-04
天津市聚星康华医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antipsychotic drug olanzapine unlikely to be effective for hallucinations in Parkinson's patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Each tablet contains 20 mg of pimavanserin tartrate, and the composition of every 1000 tablets of pimavanserin tartrate oral instant film is:

[0022] pimavanserin tartrate 20 g sodium saccharin 3g citric acid 1g pregelatinized starch 4g glycerin 2g Polyvinyl alcohol-polyethylene glycol copolymer 16g pigment 0.08g essence 1.6g purified water Appropriate amount

[0023] The preparation process is as follows:

[0024] Weigh pimavanserin tartrate, sodium saccharin, citric acid, pregelatinized starch, pigment, flavor, polyvinyl alcohol-polyethylene glycol copolymer, mix well, add purified water, stir well, add glycerin and stir uniform, centrifugal degassing, coating, drying at 60°C, stripping, and cutting according to specifications to obtain pimavanserin tartrate oral instant film.

Embodiment 2

[0026] Each tablet contains 20 mg of pimavanserin tartrate, and the composition of every 1000 tablets of pimavanserin tartrate oral instant film is:

[0027] pimavanserin tartrate 20 g Sucralose 2g citric acid 1.5g microcrystalline cellulose 4g glycerin 2g Hydroxypropylmethylcellulose 18g purified water Appropriate amount

[0028] The preparation process is as follows:

[0029] Weigh pimavanserin tartrate, sucralose, citric acid, microcrystalline cellulose, hydroxypropyl methylcellulose, mix well, add purified water, stir well, slowly swell for about 30 minutes, add glycerin Stir evenly, stand to degas, coat, dry at 60°C, remove the film, and cut according to specifications to obtain pimavanserin tartrate oral instant film.

Embodiment 3

[0031] Each tablet contains 20 mg of pimavanserin tartrate, and the composition of every 1000 tablets of pimavanserin tartrate oral instant film is:

[0032] pimavanserin tartrate 20 g aspartame 2g malic acid 2g Crospovidone 5g Titanium dioxide 0.08g glycerin 4g Pullulan 12g Menthol 0.06 ethanol Appropriate amount purified water Appropriate amount

[0033] The preparation process is as follows:

[0034] Prepare 20% pullulan glue solution and 10% menthol solution in advance. Weigh pimavanserin tartrate, aspartame, malic acid, crospovidone, glycerin, and titanium dioxide and mix evenly, then add pullulan glue and menthol solution, stir evenly, and let it stand for degassing , coated, dried at 60°C, stripped, and cut according to specifications to obtain pimavanserin tartrate oral instant film.

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PUM

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Abstract

The invention belongs to the field of medicine preparations and relates to a tartaric acid pimavanserin oral instant film and a preparation method thereof. The tartaric acid pimavanserin oral instant film is good in taste, can be quickly dissolved in the oral cavity when taken without water, and is particularly suitable for the aged and patients suffering from dysphagia. A preparation process of the tartaric acid pimavanserin oral instant film is simple and easy to implement, auxiliary materials are common and moderate in price, and industrial prospects are good. Each tartaric acid pimavanserin oral instant film contains 20 mg of tartaric acid pimavanserin. The invention further provides the preparation process of the tartaric acid pimavanserin oral instant film.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a pimavanserin tartrate oral instant film and a preparation method thereof. Background technique [0002] According to international statistics, China currently has more than 2 million Parkinson's disease patients, accounting for about 50% of the world's total. That is to say, half of the world's Parkinson's disease patients live in China. The prevalence rate of the elderly over 75 years old is as high as 10%, but about 48% of the patients are not aware of their illness, and the delayed treatment rate of early Parkinson's disease is as high as 60%. It is understood that Parkinson's disease used to be more common in the elderly, with an average age of onset of around 60 years old. It is relatively rare for people under the age of 40 to develop Parkinson's, but this situation is quietly changing now. According to specialist doctors, in recent years young patients accounte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/4468A61K47/34A61K47/36A61K47/38A61P25/16
CPCA61K9/006A61K9/7007A61K31/4468A61K47/10A61K47/36A61K47/38
Inventor 李化淋
Owner 天津市聚星康华医药科技有限公司
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