Use method of cooling agent of N-(4-methoxyphenyl)-p-menthyl-3-carboxamide

Abstract

The present invention provides a use method of a cooling agent of N-(4-methoxyphenyl)-p-menthyl-3-carboxamide. A preparation method of the cooling agent comprises the following steps: step (1), a solubilizing agent, derivatives containing menthols or derivatives of the menthol are mixed at a mass ratio of 1.0:(49.0-2.5):47.5 to be prepared into a carrier solvent; step (2), a cooling agent of WS-12 and the carrier solvent are mixed at the mass ratio of 1:(9999-1):49; and step (3), the system is subjected to a constant temperature stirring to obtain the products; and the temperature is 40-65 DEG C, the stirring speed is 500-1000 r / min, and the stirring time is 10-30 min. The effective solvent is successfully found, so that the WS-12 is dissolved into a molecular state and the cooling effects of the cooling agent are more obvious played. In addition, by using the solubilizing agent, the cooling agent can be more conveniently applied in the oily environment and the aqueous environment.

Description

Technical field [0001] The invention relates to the technical field of cooling agent application, in particular to a method for using cooling agent N-(4-methoxyphenyl)-p-menthyl-3-carboxamide. Background technique [0002] WS-12 (N-(4-methoxyphenyl)-p-menthyl-3-carboxamide) has 1.5 times the cooling sensation of menthol. It is a white powdery crystal and is a derivative of menthol, but It has completely different properties from menthol. Compared with the common cooling agents on the market, WS-12 is odorless, tasteless and basically non-volatile. It has a strong instant cooling effect and extraordinary long-lasting cooling properties. [0003] WS-12 is mainly used in oral care products, chewing gum and some other consumer products. Adding a small amount of WS-12 to berry and citrus beverages can produce a pleasant and long-lasting cooling sensation. The odorless and tastelessness of WS-12 makes it compatible with other flavors and makes it possible to be widely used. [0004] Ho...

AI Technical Summary

Problems solved by technology

[0004] However, WS-12 is difficult to dissolve in conventional solvents such as ethanol and 1,2-propanediol, and because its crystal particles are too large, it is difficult to feel the cool feeling when used directly, so there are many limitations in current use

At present, only the patent "WS-12FINEPARTICLE AND COOL-FEELING AGENT COMPOSITION CONTAINING THE SAME" (JP2016023284) provides a method of grinding WS-12 into 0.01μm~50μm particles and directly adding it to the product to improve the cool feeling. The difference is that JP2016023284 uses a physical grinding method, they did not find a way to dissolve WS-12