Microneedle array device for minimally invasive precision subcutaneous administration

Abstract

The invention discloses a microneedle array device for minimally invasive precision subcutaneous administration. The device comprises an injection pump, a hose and a five-needle-head microneedle. The injection pump comprises a lead screw, a clamp, an injection syringe, a base, a lead screw, a nut propeller, a screw rod and a stepping motor. One end of the lead screw and one end of the screw rod are connected with the stepping motor, the other end of the lead screw penetrates through the nut propeller to be fixed to the base through a support, the other end of the screw rod is directly fixed to the nut propeller, the injection syringe is fixed into a V-shaped guiding groove of the base through the clamp, a piston of the injection syringe is connected with the nut propeller, the stepping motor drives the screw rod to rotate, the screw rod rotates to drive a nut meshed with the screw rod to move linearly, the nut pushes the nut propeller to move in the guiding direction of the lead screw, and therefore the injection syringe is pushed to move rightwards, and medicine liquid in the injection syringe enters the five-needle-head microneedle through the hose. The depth of the microneedle into skin can be precisely controlled by controlling the rotating angle of the microneedle nut relative to a needle cap.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular to a microneedle array device for minimally invasive and precise subcutaneous drug delivery. Background technique [0002] Due to the natural skin barrier, the ability of most drug molecules to penetrate the skin is extremely poor, especially for macromolecular hydrophilic drugs such as insulin. Therefore, the most popular way of transdermal drug delivery at present: drug patch, the drug delivery effect is not ideal. Over the years, people have carried out a lot of work using chemical penetration enhancers and physical assistance, trying to overcome the skin barrier to enhance transdermal drug delivery. However, these methods all have different disadvantages, such as easy to cause skin allergies, and cannot effectively promote the transdermal of macromolecular drugs. The traditional one-time single-needle needle injection has always been the dominant way of subcutaneous drug deliver...

AI Technical Summary

Problems solved by technology

The simplest microneedle patch wraps the drug on the solid microneedle array and releases it at one time. Although it is simple to manufacture, it cannot achieve sustained and controlled drug delivery due to the lack of drug storage and feeding.

The complex microneedle patch integrates drug reservoirs and micropumps on hollow needle arrays through micro-electromechanical manufacturing methods, so as to achieve sustained and controlled release drug delivery, but its manufacturing cost is high

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