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Novel application of caffeic acid and derivatives thereof

A technology of caffeic acid and its derivatives, which is applied in the field of new applications of caffeic acid and its derivatives, to achieve the effect of inhibiting proliferation and broadening market prospects

Inactive Publication Date: 2016-12-07
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Caffeic acid mainly has antibacterial, antiviral, central nervous system excitatory, detoxification, and blood coagulation effects. Caffeic acid and its derivatives also have antioxidant effects, but there is no relevant report about caffeic acid and its derivatives as an angiogenesis inhibitor.

Method used

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  • Novel application of caffeic acid and derivatives thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Caffeic acid inhibits the proliferation of EA.hy926 cells

[0019] 1 Materials and methods

[0020] 1.1 Drugs and reagents

[0021] RPMI 1640 medium (Gibco company); fetal bovine serum (MDgenics company); trypsin (Hyclone company); DMSO (sigma company); CCK-8 kit (Dojindo company); caffeic acid (batch number: PS0211-0020) ( Chengdu Pusi Company, purity > 98%).

[0022] 1.2 Instruments

[0023] Cell incubator (Nuaire company); multi-functional microplate reader (Synergy HT company).

[0024] 1.3 Cell culture

[0025] Human umbilical vein endothelial cells EA.hy926 (American Type Culture Collection ATCC). Cells were seeded in culture flasks containing complete medium at 37°C, 5% CO 2 Cultivate in an incubator, change the medium once every 2-3 days, and passage at a ratio of 1:6 when the cell density is 70-80%.

[0026] 1.4 Drug preparation

[0027] Accurately weigh an appropriate amount of caffeic acid, add DMSO and 0.1mol / L PBS mixed solvent (1:7) to di...

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PUM

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Abstract

The invention provides an application of caffeic acid and derivatives thereof in preparing angiogenesis inhibitor drugs. Tests prove that the caffeic acid, which is effective on inhibiting the proliferation of vascular endothelial cells, can serve as angiogenesis inhibitors for treating such angiogenesis dependent diseases as tumors, diabetic retinopathy, rheumatoid arthritis, benign prostatic hyperplasia, or psoriasis and the like; and the caffeic acid and derivatives thereof have a broad market prospect.

Description

technical field [0001] The present invention relates to the new application of caffeic acid and its derivatives. Background technique [0002] Angiogenesis refers to the formation of new microvessels in the form of budding, bridging, or intussusception through endothelial cell migration, proliferation, differentiation, and degradation of extracellular matrix on the basis of the original microvessels, and under the regulation of related signaling pathways. The regulation process of blood vessels can be divided into physiological angiogenesis and pathological angiogenesis. Physiological angiogenesis is an orderly regulatory process that only occurs in specific periods and locations such as embryonic development and tissue damage repair. Pathological angiogenesis is associated with a series of angiogenesis-dependent diseases such as tumors, diabetic retinopathy, rheumatoid arthritis, benign prostatic hyperplasia, and psoriasis. [0003] For example, tumor growth and metastasi...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61K31/216A61P35/00A61P27/02A61P3/10A61P19/02A61P29/00A61P13/08A61P17/06
CPCA61K31/192A61K31/216
Inventor 王毓杰
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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