Taste-masking azithromycin pellet composition and preparation method thereof

Abstract

The invention relates to a composition of azithromycin taste-masking fine pellets and a preparation method thereof. The composition is composed of drug-containing fine pellets and a coating layer, wherein the drug-containing fine pellets are composed of azithromycin, a blank pellet core, a binder, and an anti-sticking agent. The drug-containing fine pellets are coated with a coating material to obtain the taste-masking fine pellets. The particle diameter of the taste-masking fine pellets is 0.08-0.20mm. The weight percentage of each component of the taste-masking fine pellets composition is as follows:

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a composition of azithromycin taste-masking fine pellets with a small particle size prepared by fluidized bed coating technology and a preparation method thereof, and azithromycin taste-masking fine pellets in the preparation field applications. Background technique [0002] Macrolide drugs mainly refer to macrolide antibiotics. Macrolide antibiotics in a broad sense refer to macrocyclic biologically active substances with lactone bonds produced by microorganisms, including general macrolides (narrowly defined macrolides), polyene macrolides, ANSA macrolides and lipopeptides, etc. At present, many new varieties of macrolide antibiotics have been developed, such as azithromycin. Azithromycin is the second-generation macrolide drug, which is mainly used to treat respiratory and reproductive tract infections, and can treat children and adults caused b...

AI Technical Summary

Problems solved by technology

[0004] Some azithromycin dosage forms for children currently on the market have some shortcomings, such as dry suspensions and granules. Due to insufficient treatment of the drug, it has a unique smell of the drug. Adding a large amount of flavoring agent cannot fundamentally solve this problem. For example, adding A large amount of sweeteners, even if the human body feels sweet at the beginning, but then feels bitter, the main reason is that the sensitive part of the human body to sense bitterness is the root of the tongue, and the root of the tongue is very sensitive to bitterness, and there is a safety risk when taking a large amount of flavoring agents

[0005] Therefore, many researchers use encapsulation techniques such as physical and chemical methods to prepare drug-containing microcapsules, physical methods such as fluidized bed coating method to prepare microcapsules or granules, spray drying method to prepare drug-containing microcapsules and microcapsules, and prepare bitter drugs. Among these methods, physical and chemical methods are widely used in experimental research, but they cannot completely encapsulate drugs, and can still produce certain bad tastes, and the production feasibility is poor; physical methods are more feasible for large-scale production, but Generally, the pellets or granules produced by the fluidized bed have a large particle size, and the taste is not good, with a gritty feel; the spray drying method produces a small particle size, but the drug loading and encapsulation efficiency are low

Images