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Methods of treating early breast cancer with trastuzumab-mcc-dm1 and pertuzumab

A pertuzumab, breast cancer technology, applied in chemical instruments and methods, antibody medical components, antibodies, etc., can solve problems such as death

Inactive Publication Date: 2016-11-23
F HOFFMANN LA ROCHE & CO AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0039] Currently utilized HER2-directed therapies for EBC leave a significant number of patients at risk of relapse and death from their disease

Method used

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  • Methods of treating early breast cancer with trastuzumab-mcc-dm1 and pertuzumab
  • Methods of treating early breast cancer with trastuzumab-mcc-dm1 and pertuzumab
  • Methods of treating early breast cancer with trastuzumab-mcc-dm1 and pertuzumab

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Experimental program
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Effect test

Embodiment 1

[0181] Phase III clinical research

[0182] This study (BO28408 / TRIO021) was a randomized, global, multicenter, open-label, III trial in treatment-naïve patients with operable, locally advanced or inflammatory, centrally assessed, HER2-positive EBC. Phase, two-arm study in patients with primary tumors >2 cm.

[0183] patient

[0184] The patient population included patients with treatment-naïve, operable, locally advanced or inflammatory, centrally confirmed HER2-positive EBC. Thus, the target population for this study included patients with newly diagnosed primary invasive breast cancer who were HER2 positive (as determined by the central pathology laboratory) and treated with adjuvant systemic chemotherapy after definitive surgery. HER2 status was tested at the center prior to randomization. The primary tumor should be >2 cm in size based on at least one radiographic or clinical measurement. A list of all suitability criteria is included below.

[0185] Investigator...

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Abstract

Methods of treating patients having HER2 -positive, operable, locally advanced or inflammatory breast cancer with the antibody-drug conjugate Trastuzumab-MCC-DMl and Pertuzumab are provided.

Description

[0001] related application [0002] This application claims the benefit under 35 U.S.C. §119 of U.S. Provisional Patent Application No. 61 / 984,132, filed April 25, 2014, the disclosure of which is hereby incorporated by reference in its entirety. [0003] sequence listing [0004] This application contains a Sequence Listing in ASCII format and is hereby incorporated by reference in its entirety. The ASCII text file was created on April 23, 2015, named GNE-0412WO_SL.txt, and is 30505 bytes in size. field of invention [0005] The present invention relates to methods of treating early breast cancer (EBC) using trastuzumab-MCC-DM1 and pertuzumab. Background of the invention [0006] Breast cancer and HER2-targeted therapy [0007] Breast cancer is a highly significant cause of morbidity and mortality worldwide. More than 1.3 million cases of breast cancer are diagnosed worldwide each year, and more than 450,000 deaths are associated with the disease (Jemal A, Bray F, Cent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61P35/00
CPCC07K16/32A61K2039/545A61K2039/55A61K2039/507C07K2317/94A61K47/68033A61K39/395A61K31/513A61K31/5365A61K31/675A61K31/704A61K39/39558C07K2317/72A61K47/6855A61K47/6869A61K47/6871A61P35/00A61P35/04A61P43/00A61K2300/00A61K39/3955A61K47/6803C07K2317/24
Inventor M·C·格林A·E·瓜尔迪诺
Owner F HOFFMANN LA ROCHE & CO AG
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