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Asiaticoside-based compound medicine for treating depression

A technology of asiaticoside and depression, which is applied in the field of asiaticoside-based compound drugs for treating depression, can solve the problems that patients are easy to give up, and achieve the effects of reducing economic burden, simple preparation, and low price

Inactive Publication Date: 2016-11-23
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most patients hope that the symptoms can be relieved immediately after treatment, but it usually takes 2-4 weeks on average for traditional Chinese medicine or natural medicine to take effect, which makes some patients easy to give up treatment at the initial stage

Method used

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  • Asiaticoside-based compound medicine for treating depression
  • Asiaticoside-based compound medicine for treating depression
  • Asiaticoside-based compound medicine for treating depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Preparation of pharmaceutical composition granules

[0033] The content of components used in this embodiment is: asiaticoside 1.2g, borneol 3g, starch 40g, dextrin 30g, low-substituted hydroxypropyl cellulose 5g, 60% ethanol, propylene glycol, magnesium stearate 1g.

[0034] The preparation process of this example is as follows: mix the asiaticoside, borneol, starch, dextrin, and low-substituted hydroxypropyl cellulose in the proportion of the above raw materials, and add an appropriate amount of propylene glycol and 60% ethanol to the mixed powder , mixed evenly to make soft materials, granulated through a 16-mesh sieve, and dried below 45°C. After the drying is completed, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and pack in 400 bags to get the final product.

Embodiment 2

[0036] Preparation of pharmaceutical composition granules

[0037] The content of components used in this embodiment is: asiaticoside 0.6g, borneol 3g, starch 40g, dextrin 30g, low-substituted hydroxypropyl cellulose 5g, 60% ethanol, propylene glycol, and magnesium stearate 1g.

[0038] The preparation process of this example is as follows: mix the asiaticoside, borneol, starch, dextrin, and low-substituted hydroxypropyl cellulose in the proportion of the above raw materials, and add an appropriate amount of propylene glycol and 60% ethanol to the mixed powder , mixed evenly to make soft materials, granulated through a 16-mesh sieve, and dried below 45°C. After the drying is completed, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and pack in 400 packages to obtain the product.

Embodiment 3

[0040] Preparation of asiaticoside granules

[0041] The content of components used in this embodiment is: asiaticoside 1.2g, starch 40g, dextrin 30g, low-substituted hydroxypropyl cellulose 5g, 60% ethanol, propylene glycol, magnesium stearate 1g.

[0042] The preparation process of this embodiment is as follows: mix the asiaticoside, starch, dextrin, and low-substituted hydroxypropyl cellulose in the proportion of the above raw materials evenly, and additionally take an appropriate amount of propylene glycol and 60% ethanol, add them to the mixed powder, and mix After homogenization, make soft material, granulate through 16 mesh sieve, and dry below 45°C. After the drying is completed, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and pack in 400 packages to obtain the product.

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Abstract

The invention discloses an asiaticoside-based compound medicine for treating depression and belongs to the technical field of medical treatment. The compound medicine comprises asiaticoside and borneol. Compared with a medicine in which asiaticoside of the same dose is used alone, the compound medicine disclosed by the invention is higher in curative effect, and has the characteristics of fast effectiveness and obvious effect. In order to overcome the defects of antidepressant drugs in clinical application, particularly the defects such as great side effects and high treatment cost when the drugs are taken for a long time, the invention provides a pharmaceutical composition which is fast in effectiveness, low in price and small in side effects. According to combined application of asiaticoside and the traditional Chinese medicine borneol, a better treatment effect can be achieved compared with that of single use of asiaticoside. The experiments prove that the pharmaceutical composition can enhance the treatment effect of the medicine and reduce the actual dosage of the asiaticoside, so that the treatment cost is greatly reduced.

Description

technical field [0001] The invention relates to a technology in the field of pharmacy, in particular to a compound medicine for treating depression based on asiaticoside. Background technique [0002] Depressive disorder has become a common disease. Epidemiological studies show that the incidence rate of depression worldwide is about 3.1%, and it currently ranks fourth among disabling diseases in the world, and is expected to rank second by 2020, second only to ischemic heart disease. The incidence of depression in China is about 3% to 5%, and there are more than 26 million patients at present. In 2004, the results of 15 surveys on depression in 14 countries showed that the annual prevalence of depression was 0.8%-9.6%, with the highest in the United States and the lowest in Nigeria; 2.5% and 2.5% in Beijing and Shanghai, respectively. 1.7%. According to the 2002 World Health Organization Report, according to the current growth rate of the incidence rate, depression may b...

Claims

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Application Information

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IPC IPC(8): A61K31/7024A61K31/045A61K9/08A61K9/16A61K9/48A61P25/24
CPCA61K31/7024A61K9/0053A61K9/08A61K9/1652A61K31/045A61K47/10A61K47/26A61K2300/00
Inventor 彭崇胜李晓波侯天衡
Owner SHANGHAI JIAO TONG UNIV
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