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Hollow Fiber Membrane Module for Platelet Suspension Cleaning

A fiber membrane and platelet technology, applied in the field of hollow fiber membrane modules, can solve the problems of complex operation, low platelet recovery rate, long processing time, etc., and achieve the effect of low total protein content

Active Publication Date: 2018-09-18
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, since it is difficult to completely remove the supernatant, multiple separations are required to sufficiently reduce the total protein amount, which has the problems of complicated operation, long processing time, and low platelet recovery rate.

Method used

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  • Hollow Fiber Membrane Module for Platelet Suspension Cleaning
  • Hollow Fiber Membrane Module for Platelet Suspension Cleaning
  • Hollow Fiber Membrane Module for Platelet Suspension Cleaning

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0186] After mixing and dissolving a mixture consisting of 15 parts of Yudel (registered trademark) polysulfone (P3500; Solbey Company), 8 parts of PVP (K90; ISP Company), 75 parts of DMAC and 2 parts of water at 90°C, the temperature was kept at 50°C. The mixture at ℃ was used as the membrane stock solution. In addition, a mixture obtained by adding 30 parts of PVP (K30; ISP company) to a mixed solution consisting of 80 parts of DMAC and 20 parts of water and mixing and dissolving it was used as a core liquid.

[0187] Using a hole-type double-cylindrical nozzle with an outer diameter of 1.0mm / inner diameter of 0.7mm, the film-forming stock solution is sprayed from the outer cylinder at the same time, and the core solution is sprayed from the inner cylinder, making it pass through the length set at 30°C After the dry part of 70mm was formed, it was immersed in a 90°C coagulation bath containing a mixed solution consisting of 85 parts of water and 15 parts of DMAC to solidify ...

Embodiment 2

[0193] A hollow fiber membrane module was produced in the same manner as in Example 1, except that the inner diameter of the cylindrical member was 44 mm, the volume of the top cover was 6.4 mL, and the number of inserted hollow fiber membranes was 5243.

[0194] The effective length (L) of the hollow fiber membrane is 255mm, and the cross-sectional area (A) of the hollow part of the hollow fiber membrane (the cross-sectional area of ​​the inflow side space perpendicular to the length direction of the shell) is 0.00037m 2 . Therefore, the value of the ratio (L / A) of the effective length (L) of the hollow fiber membrane to the cross-sectional area (A) of the hollow portion of the hollow fiber membrane (L / A) is 689m -1 . The volume of the inflow-side space of the hollow fiber membrane module was 118 mL. The water permeability of the hollow fiber membrane module is 95mL / Pa / hr. The porosity of the surface of the hollow fiber membrane in the inflow side space is 17.3%, and the p...

Embodiment 3

[0197] A hollow fiber membrane module was produced in the same manner as in Example 1, except that the inner diameter of the cylindrical member was 40 mm, the volume of the top cover was 5.3 mL, and the number of inserted hollow fiber membranes was 4494.

[0198] The effective length (L) of the hollow fiber membrane is 255mm, and the cross-sectional area (A) of the hollow part of the hollow fiber membrane (the cross-sectional area of ​​the inflow side space perpendicular to the length direction of the shell) is 0.00032m 2 . Therefore, the value of the ratio (L / A) of the effective length (L) of the hollow fiber membrane to the cross-sectional area (A) of the hollow portion of the hollow fiber membrane (L / A) is 796m -1 . The volume of the inflow-side space of the hollow fiber membrane module was 101 mL. The water permeability of the hollow fiber membrane module is 82mL / Pa / hr. The porosity of the surface of the hollow fiber membrane in the inflow side space was 17.3%, and the ...

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Abstract

The present invention aims to provide a hollow fiber membrane module capable of producing washed platelets having a low total protein amount and a high total platelet count from a platelet suspension. The present invention provides a hollow fiber membrane module for washing platelets by removal of impurities from a platelet suspension, comprising: a housing having a platelet suspension inlet, washed platelet outlet, and filtrate outlet; and a hollow fiber membrane for filtering the platelet suspension, wherein pores through which the platelets do not pass, while the impurities pass, are formed, which hollow fiber membrane is arranged inside the housing; wherein the capacity of the inlet-side space which communicates with the platelet suspension inlet and stores the platelet suspension before being filtered through the hollow fiber membrane in the housing is 30 to 400 mL, and the module water permeability is 50 to 300 mL / Pa / hr.

Description

technical field [0001] The present invention relates to a hollow fiber membrane module used for washing and removing protein in platelet suspension. Background technique [0002] Platelet preparations are produced by centrifuging blood components collected from blood donors to remove blood cell components from the blood, thereby forming a platelet suspension state in which platelets float in plasma. Therefore, when the platelet preparation is transfused, the protein in the plasma sometimes becomes one of the causes of non-hemolytic blood transfusion side effects. In order to reduce the frequency of non-hemolytic blood transfusion side effects, it is recommended to use platelets that have been washed to remove impurities such as proteins (washed platelets). Washed platelets are produced by physically separating and removing impurities such as proteins from the platelet suspension, and methods for separating and removing proteins from the platelet suspension include centrifug...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M1/02B01D63/02B01D69/08B01D71/68
CPCA61M1/0281A61M2202/0427B01D63/02B01D2315/08B01D2325/02B01D2325/04B01D2325/36
Inventor 野坂史朗上野良之长部真博岸川龙也
Owner TORAY IND INC
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