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Application of Ligularia jaluensis in preparation of xanthine oxidase inhibitors

A xanthine oxidase and inhibitor technology, applied in the field of xanthine oxidase inhibitors derived from traditional Chinese medicine, can solve problems such as elevated blood uric acid

Active Publication Date: 2016-11-09
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention provides the application of a complex sequence Lignus in the preparation of xanthine oxidase inhibitors to solve the problem of abnormally elevated blood uric acid in hyperuricemia, gout and other related diseases

Method used

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  • Application of Ligularia jaluensis in preparation of xanthine oxidase inhibitors
  • Application of Ligularia jaluensis in preparation of xanthine oxidase inhibitors
  • Application of Ligularia jaluensis in preparation of xanthine oxidase inhibitors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 acute toxicity test

[0018] Due to the limitation of administration concentration and administration volume, the LD50 of intragastric administration to mice could not be measured, and the water suspension, water extract, ethanol extract, and methanol extract of compound sequence Ligwu herb were pulverized at 90ml / kg dose was given to mice for intragastric administration, the animals were in good condition, and no acute toxic reaction was seen. The maximum dose of intragastric administration for mice in one day was ≥ 90ml (four kinds of extracts were respectively equivalent to crude drug amounts of 95.5g / kg, 110.5g / kg, 130.0g / kg, 135.0g / kg).

Embodiment 2

[0019] Example 2: The application of Ligularia complex to prepare uric acid-lowering products

[0020] 1. Ligularia jaluensis capsule (LJC): collect Ligularia jaluensis, dry in the shade, crush to make a hard capsule preparation.

[0021] 2. Ligularia jaluensis tablet (LJT): Collect Ligularia jaluensis, dry in the shade, pulverize, ultrasonically extract with 10 times the amount of 75% ethanol three times, each time for 30 minutes, filter, combine the filtrates, and evaporate to dryness , pulverize, add appropriate amount of starch, and press into tablets.

[0022] 3. Ligularia jaluensis oral liquid (LJOL): take Ligularia jaluensis oral liquid, decoct in 10 times the amount of water for 40 minutes, filter, concentrate the filtrate to obtain liquid extract, add auxiliary materials, and make oral liquid .

Embodiment 3

[0023] Example 3: Study on the Activity of Fuxu Liwu Lowering Uric Acid Products

[0024] 1 material

[0025] 1.1 Medicinal materials and reagents

[0026] Compound sequence Liwu, the fruit of Sorbus pohuashanensis, a plant of Rosaceae Sorbus, is collected from the Linjiang area of ​​Changbai Mountains. Xanthine (XA) and xanthine oxidase (XOD) were purchased from Sigma, USA; allopurinol was purchased from Shanghai Aladdin Reagent Company; other reagents were domestic analytical grade.

[0027] 1.2 Instruments

[0028] Thermo Multiskan GO full-wavelength microplate reader (Thermo Fisher Scientific); ABS 320-4N analytical balance (Shanghai Daohan Industrial Co., Ltd.); KQ-250B CNC ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.) ; RE-52AA rotary evaporator (Shanghai Yarong Biochemical Instrument Factory); DZF6020 vacuum dryer (Shanghai Yiheng Scientific Instrument Co., Ltd.).

[0029] 2 methods

[0030] Xanthine oxidase inhibitory activity of phenolic acids and ...

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Abstract

The invention relates to application of Ligularia jaluensis in preparation of xanthine oxidase inhibitors, and belongs to the field of traditional Chinese medicine. The invention discloses use of Ligularia jaluensis and an extract thereof as active components in the preparation of the xanthine oxidase inhibitors, wherein the Ligularia jaluensis and the extract thereof comprise a Ligularia jaluensis original plant and a solvent extract thereof, and the solvent extract comprises water, ethanol and methanol extracts. The application has the beneficial effects that the problem of abnormal blood uric acid rise of related diseases such as hyperuricemia and arthrolithiasis is solved, and arthralgia and swelling distortion caused by the diseases such as hyperuricemia and uarthritis as well as related symptoms for the diseases such as hypertension, diabetes, cardiovascular diseases, kidney diseases and metabolic syndrome are indirectly solved and relieved.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a xanthine oxidase inhibitor derived from traditional Chinese medicine. Background technique [0002] If the uric acid level in the body continues to be high and supersaturated, sodium urate crystals will be deposited in the joints and surrounding tissues, resulting in gout, a purine metabolic disease. Hyperuricemia is an important sign of gout. About 5% to 12% of hyperuricemia will eventually develop into gout, and 80% to 90% of gout patients are accompanied by hyperuricemia. In addition, hyperuricemia is also closely related to the occurrence of hypertension, diabetes, cardiovascular disease, kidney disease, metabolic syndrome and other diseases. The incidence of gout varies greatly between regions. Its incidence is only 0.03% in Nigeria, but as high as 15.2% among the aborigines of Taiwan. Epidemiological surveys show that due to the improvement of people's living...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61P19/06A23L33/105
Inventor 李海军刘菲涂正坤翟乃翠高永梅
Owner JILIN UNIV
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