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Application of phillyrin, phillyrin derivatives, and phillyrin-phillygenin composition in preparation of drugs for prevention or/and treatment of liver injury

A technology of forsythin derivatives and forsythiatin, which is applied in the field of medicine and can solve problems such as allergic reactions and immunogenicity

Active Publication Date: 2016-11-02
富力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, at this stage, the serine protease inhibitors used clinically in my country are bovine lung extracts, which will produce immunogenicity as heterologous proteins, especially when used in large quantities in clinical practice, allergic reactions will occur

Method used

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  • Application of phillyrin, phillyrin derivatives, and phillyrin-phillygenin composition in preparation of drugs for prevention or/and treatment of liver injury
  • Application of phillyrin, phillyrin derivatives, and phillyrin-phillygenin composition in preparation of drugs for prevention or/and treatment of liver injury
  • Application of phillyrin, phillyrin derivatives, and phillyrin-phillygenin composition in preparation of drugs for prevention or/and treatment of liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1 forsythin tablet

[0055] 1. Prepare raw materials according to the following ratio

[0056]

[0057]

[0058] 2. Mix forsythin and starch evenly, make granules, add talcum powder and magnesium stearate, mix evenly, and press into 10,000 tablets.

Embodiment 2

[0059] Embodiment 2 forsythin capsules

[0060] 1. Prepare raw materials according to the following ratio

[0061] Forsythin (purity 60%) 200g

[0062] Starch 1000g

[0063] 2. Mix forsythin and starch evenly and pack into capsules to make 10,000 capsules.

Embodiment 3

[0064] Embodiment 3 forsythin capsules

[0065] 1. Prepare raw materials according to the following ratio

[0066] Forsythin (purity 98%) 500g

[0067] Starch 1000g

[0068] 2. Mix forsythin and starch evenly and pack into capsules to make 10,000 capsules.

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Abstract

The invention discloses new application of phillyrin, phillyrin derivatives, and a phillyrin-phillygenin composition in preparation of drugs or health products for liver protection, liver care and liver injury resistance. Tests prove that the phillyrin, phillyrin derivatives, and phillyrin-phillygenin composition have the characteristics of significant liver protection, liver care and liver injury resistance effect, quick effect and small toxic and side effect, are a safe, efficient and stable liver protection and liver injury resistance drug with a simple preparation process, and are suitable for industrial production and easy for popularization. The invention provides a new drug source for liver protection and liver injury resistance.

Description

technical field [0001] The invention relates to the field of medicine, and relates to a liver-protecting and anti-liver damage drug or health food, in particular to an application of traditional Chinese medicine forsythia and forsythia leaf extract components in liver protection and liver damage drugs or health food. Background technique [0002] The liver is the largest metabolic organ and digestive gland in the body. Almost all substances absorbed from the gastrointestinal tract enter the liver, where they are synthesized, decomposed, transformed, and stored. The liver is also an important immune organ of the body. Various harmful factors and substances, such as viruses, poisons, drugs, ethanol, hypoxia, immunity, etc., can act on liver tissue, which can directly cause damage to liver cells to varying degrees, and can also cause liver cell damage through the activation of cytokine networks. Injury, regeneration, liver fibrosis, and advanced liver failure. The research on...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K36/258A61K36/9066A61K36/484A61K36/489A61K36/282A61K36/71A61K36/65A61K36/232A61K36/481A61P1/16A23L33/10A61K31/34A61K31/375A61K31/355
CPCA61K31/34A61K31/355A61K31/375A61K31/7048A61K36/232A61K36/258A61K36/282A61K36/481A61K36/484A61K36/489A61K36/65A61K36/71A61K36/9066A23V2002/00A61K2300/00A23V2200/32
Inventor 付强富力王凯乾惠敏冯雪鲁明明盖鑫刘正贤
Owner 富力
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