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Cd44 binding peptides

一种蛋白质、基因的技术，应用在蛋白质领域，能够解决代价高昂、生产方法复杂等问题

Inactive Publication Date: 2016-10-26
EXCHANGE IMAGING TECH GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a result, the production methods described are complex, costly and have to strictly comply with regulatory requirements

Method used

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Examples

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Embodiment approach

[0210] As one embodiment of the present invention, the composition is prepared by using CD44ex9-binding protein or CD44v5 peptide with stable human serum albumin. To this end, CD44ex9 binding protein or CD44v5 peptide was prepared by lyophilization with human serum albumin in vials.

[0211] In certain embodiments, the pharmaceutical composition further comprises one or more other drugs that are toxins, cytokines, cytostatic agents, or immunomodulators.

[0212] As used herein, the term "pharmaceutically acceptable carrier" is intended to include any and all solvents, solubilizers, fillers, stabilizers, binders, absorbents, bases, buffers, lubricants, release-controlling Excipients, diluents, emulsifiers, humectants, lubricants, dispersion media, coatings, antibacterial or antifungal agents, isotonic and absorption delaying agents, and the like are compatible carriers for pharmaceutical administration. Such media and agents for pharmaceutically active substances are known in ...

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Abstract

The present invention relates to a protein which binds to the domain encoded by exon 9 of human CD44 (CD44ex9), to fusion proteins and conjugates of said protein and especially to nanoparticles conjugated to said protein. The invention further relates to a method of production for the protein and the respective conjugated nanoparticles and the use of the protein of the invention for treatment and diagnosis of cancer diseases.

Description

technical field [0001] The present invention relates to a protein that binds to a region encoded by exon 9 of the human CD44 gene (CD44ex9) to fuse and couple to the protein, and in particular to nanoparticles coupled to the protein. The present invention also relates to a method for the production of said proteins and corresponding conjugated nanoparticles, to CD44V5-derived peptides, and to the use of the proteins and peptides of the present invention in the treatment and diagnosis of various diseases, especially in the treatment and Applications in the diagnosis of cancer. Background technique [0002] Extensive studies of cancer transcriptional patterns have led to the discovery of molecular targets to distinguish malignant from benign tumors and the most aggressive tumors from those that are less aggressive. Cancers tend to overexpress some proteins, including certain cell surface antigens, for example, cell surface receptors. Antibodies that bind to these overexpress...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/16C07K14/705A61P35/00C12N15/11
CPCA61K38/00A61K49/0056A61K49/0067G01N33/587G01N2333/70585A61K47/62A61K47/6929C07K14/70585A61P1/04A61P17/04A61P25/00A61P29/00A61P35/00A61P37/08A61P3/10A61K38/1709C07K5/06G01N33/574G01N33/57492
Inventor 克劳迪娅·阿恩茨沃尔夫冈·格雷布
Owner EXCHANGE IMAGING TECH GMBH
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