Three-dimensional ion mobility combinational mass spectrometer

Abstract

The invention belongs to the technical field of sample separation and analysis of isomeride, and specifically to a three-dimensional ion mobility combinational mass spectrometer. The three-dimensional ion mobility mass spectrometer comprises an ionization source module, an ion mobility module and a mass spectrometry detector module, wherein the ionization source module comprises an ion source spraying needle and a desolvation region; the ion mobility module comprises a first ion focusing lens, an ion trap, an inlet end baffle, a buffering gas outlet, annular electrodes, heating rings, strong asymmetric electrodes, a buffering gas inlet and a second ion focusing lens; the mass spectrometry detector module comprises an ion transmission four-stage rod and a flight time mass spectrum; the centers of the ionization source module, the ion mobility module and the mass spectrometry detector module are on the same axle wire; the ionization source module is connected to the first ion focusing lens of the ion mobility module; and the ion mobility module is connected with an ion transmission focusing apparatus of the mass spectrometry detector module through the second ion focusing lens. According to the three-dimensional ion mobility combinational mass spectrometer, the annular overlapped electrodes are adopted to drive ions to fly, and the buffering gas enters from the negative direction; and meanwhile, a one-dimensional electric field is further added to the third dimension, so that the collision probability between the buffering gas and ions is increased, and the separation efficiency is greatly increased.

Description

technical field [0001] The invention belongs to the technical field of separation and analysis of isomer samples, and in particular relates to a three-dimensional ion mobility mass spectrometer. Background technique [0002] The separation of isomers has always been a major difficulty in the separation and analysis of biomedicine and other fields, and this difficulty has also caused a lag in the resolution of many problems. For example, polysaccharide isomers in biological samples carry many biomarkers and play a vital role in the prediction, diagnosis, treatment and metabolism of diseases. However, the inherent structural differences of polysaccharides are the biggest challenge in the comprehensive analysis of polysaccharides, and it is also one of the main reasons why glycomics lags behind proteomics and genomics. The molecular weights of these isomers are exactly the same. If only traditional methods are used for separation and detection, such as liquid chromatography, i...

AI Technical Summary

Problems solved by technology

For strong asymmetric field ion mobility, although the resolution of ion mobility technology can be effectively improved, in this technology, ions are driven by buffer gas. Compared with traditional ion mobility technology, ions and The chance of buffer gas collision is relatively reduced

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