Hydrogel photonic crystal microspheres, and preparation method and application thereof

A technology of photonic crystal microspheres and hydrogels, which is applied in the preparation of microspheres, microcapsule preparations, and material analysis through optical means, and can solve the problem of reducing the accuracy and applicability of hydrogel photonic crystals and making it difficult to prepare photonic crystals microspheres etc.

Active Publication Date: 2016-10-26
HUAZHONG UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0004] Although the preparation process of traditional hydrogel photonic crystals is relatively simple, the response time of hydrogel photonic crystals to small molecules is as long as tens of minutes to several hours; for example, although the process of non-spherical hydrogel photonic crystal films is simple , can be prepared quickly, but the photonic crystal film has angle dependence, and the film has different colors when viewed at different angles, which reduces the accuracy and applicability of this hydrogel photonic crystal in detection
At the same time, traditional photonic crystal microspheres based on silica and polystyrene nanoparticles are not responsive to external conditions (such as temperature, solvent, and mechanical force, etc.), and it is difficult to prepare photonic crystals that can observe color changes with the naked eye. Microspheres

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  • Hydrogel photonic crystal microspheres, and preparation method and application thereof
  • Hydrogel photonic crystal microspheres, and preparation method and application thereof
  • Hydrogel photonic crystal microspheres, and preparation method and application thereof

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preparation example Construction

[0045] The preparation method of the photonic crystal microsphere comprises the following steps:

[0046] (1) Preparation of silica emulsion droplets: uniformly disperse tetraethyl orthosilicate and ammonia water in ethanol, and stir at constant temperature for 6 hours; after the reaction, centrifugally purify to obtain silica nanoparticles, and silica nanoparticles The particles are dispersed in water to obtain a suspension; the particle size of the silica nanoparticles in the suspension is 50-500nm, preferably 200-300nm (especially 200nm-250nm), and the mass concentration is 5-20%, preferably 10-15 %; Using microfluidic technology, the aforementioned silica nanoparticle suspension is used as the dispersed phase, and under the shear force of the continuous phase simethicone oil, the dispersed phase forms monodisperse emulsion droplets. The flow rate of the internal water phase is 50-500 μL / h, and the flow rate of the continuous phase is 2000-6000 μL / h; the internal diameter o...

Embodiment 1

[0057] The preparation method of the inverse opal structure hydrogel photonic crystal microsphere in this embodiment comprises the following steps:

[0058] (1) Preparation of silica emulsion droplets: uniformly disperse tetraethyl orthosilicate and ammonia water in ethanol, and stir at constant temperature for 6 hours; after the reaction, centrifugal purification is obtained to obtain silica nanoparticles, and the silica nanoparticles Disperse in water to obtain a suspension; the particle size of the silica nanoparticles in the suspension is 245nm, and the mass concentration is 10%; using microfluidic technology, the aforementioned silica nanoparticle suspension is used as the dispersed phase, and in Under the shear force of the continuous phase simethicone, the dispersed phase forms monodisperse emulsion droplets. The flow rate of the dispersed phase is 300 μL / h, and the flow rate of the continuous phase is 3000 μL / h; the inner diameter of the internal capillary used in the ...

Embodiment 2

[0065] In this embodiment, the preparation method of the inverse opal structure hydrogel photonic crystal microsphere comprises the following steps:

[0066] (1) Preparation of silica emulsion droplets: uniformly disperse tetraethyl orthosilicate and ammonia water in ethanol, and stir at constant temperature for 6 hours; after the reaction, centrifugally purify to obtain silica nanoparticles, and silica nanoparticles The particles are dispersed in water to obtain a suspension; the particle size of the silica nanoparticles in the suspension is 245nm, and the mass concentration is 10%; using microfluidic technology, the aforementioned silica nanoparticle suspension is used as the dispersed phase, Under the shear force of the continuous phase simethicone, the dispersed phase forms monodisperse emulsion droplets. The flow rate of the dispersed phase is 300 μL / h, and the flow rate of the continuous phase is 3000 μL / h; the inner diameter of the internal capillary used in the microfl...

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Abstract

The invention discloses hydrogel photonic crystal microspheres, and a preparation method and an application thereof. The preparation method comprises the steps of (1) preparation of silica emulsion droplets, (2) preparation of silica photonic crystal microspheres, (3) preparation of silica-hydrogel hybrid photonic crystal microspheres, and (4) preparation of inverse-opal-structured hydrogel photonic crystal microspheres. In the step (3), acrylamide, acrylic acid, methylene bisacrylamide and a photo-initiator are allowed to penetrate into the silica photonic crystal microspheres; ultraviolet irradiation is carried out, such that acrylamide and acrylic acid monomers are cured, such that the silica-hydrogel hybrid photonic crystal microspheres are obtained. With the method provided by the invention, the obtained hydrogel photonic crystal microspheres have a three-dimensional ordered porous structure, wherein the pores have a compact hexagonal stacking ordered structure. With the method, technical problems of angle dependence and slow response to small molecules of existing hydrogel photonic crystal films can be solved.

Description

technical field [0001] The invention belongs to the field of responsive photonic crystals, and more specifically relates to a hydrogel photonic crystal microsphere and its preparation and application. response. Background technique [0002] A photonic crystal is a periodic microstructure composed of materials with different refractive indices alternately in space. Its most fundamental feature is that it has a photonic forbidden band, that is, the light falling in the forbidden band is prohibited from propagating. Due to its unique optical properties, photonic crystals are widely used in the preparation of various optical devices such as filters, sensors, displays, etc.; in addition, they also play an important role in clinical diagnosis, gene analysis, drug screening and other fields. [0003] Inverse opal-structured hydrogel photonic crystal microspheres with fast response to pH and glucose are a class of responsive polymer optical materials with nano-macropore three-dimen...

Claims

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Application Information

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IPC IPC(8): B01J13/02G01N21/78
CPCB01J13/02G01N21/78G01N2021/775
Inventor 朱锦涛李诚念杨亚江
Owner HUAZHONG UNIV OF SCI & TECH
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